Tumor suppressors and cell metabolism: a recipe for cancer growth. - Wikidata - awgldk - TriplyDB

Tumor suppressors and cell metabolism: a recipe for cancer growth.

Tumor suppressors and cell metabolism: a recipe for cancer growth.

http://www.wikidata.org/entity/Q37390879

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Cancer as a metabolic disease Identification of small molecule inhibitors of pyruvate kinase M2 Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinase Mitochondrial pyrimidine nucleotide carrier (PNC1) regulates mitochondrial biogenesis and the invasive phenotype of cancer cells MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells Regulation of glucose metabolism by p53: emerging new roles for the tumor suppressor HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species Insights into the Regulatory Role of Non-coding RNAs in Cancer Metabolism Intracellular Mono-ADP-Ribosylation in Signaling and Disease Metabolic interplay between glycolysis and mitochondrial oxidation: The reverse Warburg effect and its therapeutic implication Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies Recent treatment advances and novel therapeutic approaches in epilepsy AMPK as a potential anticancer target - friend or foe?Restoration of mitochondria function as a target for cancer therapy Autophagy and cancer Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming Novel therapeutic targets of tumor metabolism Two-way communication between the metabolic and cell cycle machineries: the molecular basis The metabolic basis of kidney cancer Combined inhibition of glycolysis and AMPK induces synergistic breast cancer cell killing.Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab Assessment, origin, and implementation of breath volatile cancer markers.Pathway connectivity and signaling coordination in the yeast stress-activated signaling network.Toward precision medicine of breast cancer Adipose tissue dysfunction and its effects on tumor metabolism RAS oncogenes: weaving a tumorigenic web The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged Effects of Interferons and Viruses on Metabolism Systems biology of cancer: entropy, disorder, and selection-driven evolution to independence, invasion and "swarm intelligence"Role of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: potential prospects for combined targeted therapeutics (review)Sustained proliferation in cancer: Mechanisms and novel therapeutic targets Structure-based development of small molecule PFKFB3 inhibitors: a framework for potential cancer therapeutic agents targeting the Warburg effect Magnetic resonance spectroscopy detectable metabolomic fingerprint of response to antineoplastic treatment Differential expression of metabolic genes in tumor and stromal components of primary and metastatic loci in pancreatic adenocarcinoma Detection of rapalog-mediated therapeutic response in renal cancer xenografts using ⁶⁴Cu-bevacizumab immunoPET Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN Integrated proteomics identified up-regulated focal adhesion-mediated proteins in human squamous cell carcinoma in an orthotopic murine model.Strategies of eradicating glioma cells: a multi-scale mathematical model with MiR-451-AMPK-mTOR control

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Tumor suppressors and cell metabolism: a recipe for cancer growth.

http://www.wikidata.org/entity/Q37390879

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on March 2009

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Tumor suppressors and cell metabolism: a recipe for cancer growth.

@en

Tumor suppressors and cell metabolism: a recipe for cancer growth.

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type

label

Tumor suppressors and cell metabolism: a recipe for cancer growth.

@en

Tumor suppressors and cell metabolism: a recipe for cancer growth.

@nl

prefLabel

Tumor suppressors and cell metabolism: a recipe for cancer growth.

@en

Tumor suppressors and cell metabolism: a recipe for cancer growth.

@nl

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Genes & Development

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Tumor suppressors and cell metabolism: a recipe for cancer growth.

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Craig B Thompson

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Russell G Jones

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P2860

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control.

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1

AMPK phosphorylation of raptor mediates a metabolic checkpoint

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha.

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

A restriction point for control of normal animal cell proliferation

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537-548

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scholarly article

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10.1101/GAD.1756509

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5

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23

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2009-03-01T00:00:00Z

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24185670

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19270154

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2763495

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