Identification of ciliary neurotrophic factor (CNTF) residues essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists.
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The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokineEnhancing B- and T-cell immune response to a hepatitis C virus E2 DNA vaccine by intramuscular electrical gene transfer.The N-terminal cytokine binding domain of LIFR is required for CNTF binding and signalingInterleukin-11 signals through the formation of a hexameric receptor complexReceptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6.Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling.Receptor recognition by gp130 cytokines.IL-27 structural analysis demonstrates similarities with ciliary neurotrophic factor (CNTF) and leads to the identification of antagonistic variantsFunctional characterization of W147A: a high-affinity interleukin-11 antagonistCiliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistanceInterleukin-6: structure-function relationships.A unique loop structure in oncostatin M determines binding affinity toward oncostatin M receptor and leukemia inhibitory factor receptorCiliary neurotrophic factor receptor regulation of adult forebrain neurogenesis.Molecular interactions within the IL-6/IL-12 cytokine/receptor superfamily.The Leukemia Inhibitory Factor Receptor Gene Is a Direct Target of RUNX1.Mapping of the leptin binding sites and design of a leptin antagonist.Leukemia inhibitory factor (LIF), cardiotrophin-1, and oncostatin M share structural binding determinants in the immunoglobulin-like domain of LIF receptor.Leptin receptor-mediated regulation of cholinergic neurotransmitter phenotype in cells of central nervous system origin.An antagonist for the leukemia inhibitory factor receptor inhibits leukemia inhibitory factor, cardiotrophin-1, ciliary neurotrophic factor, and oncostatin M.LIF receptor-gp130 interaction investigated by homology modeling: implications for LIF binding.Molecular dissection of human interleukin-31-mediated signal transduction through site-directed mutagenesis.Agonistic and Antagonistic Variants of Ciliary Neurotrophic Factor (CNTF) Reveal Functional Differences between Membrane-bound and Soluble CNTF α-Receptor
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P2860
Identification of ciliary neurotrophic factor (CNTF) residues essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on August 1996
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Identification of ciliary neur ...... of CNTF receptor antagonists.
@en
Identification of ciliary neurotrophic factor
@nl
type
label
Identification of ciliary neur ...... of CNTF receptor antagonists.
@en
Identification of ciliary neurotrophic factor
@nl
prefLabel
Identification of ciliary neur ...... of CNTF receptor antagonists.
@en
Identification of ciliary neurotrophic factor
@nl
P2093
P2860
P356
P1476
Identification of ciliary neur ...... n of CNTF receptor antagonists
@en
P2093
P2860
P304
P356
10.1073/PNAS.93.17.9247
P407
P577
1996-08-01T00:00:00Z