Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor.
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The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptorStructure of a nanobody-stabilized active state of the β(2) adrenoceptorPotential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigationLigand-specific regulation of the extracellular surface of a G-protein-coupled receptorA Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic ReceptorPredicting novel binding modes of agonists to β adrenergic receptors using all-atom molecular dynamics simulationsDeterminants involved in subtype-specific functions of rat trace amine-associated receptors 1 and 4Investigation of D₂ receptor-agonist interactions using a combination of pharmacophore and receptor homology modeling.Analysis of full and partial agonists binding to beta2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes.The essential role for aromatic cluster in the β3 adrenergic receptorComparative molecular field analysis of fenoterol derivatives: A platform towards highly selective and effective beta(2)-adrenergic receptor agonists.Ligand-directed signalling at beta-adrenoceptorsThe effect of stereochemistry on the thermodynamic characteristics of the binding of fenoterol stereoisomers to the beta(2)-adrenoceptorAgonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptorMolecular basis of ligand dissociation in β-adrenergic receptorsModeling of ligand binding to G protein coupled receptors: cannabinoid CB1, CB2 and adrenergic β 2 AR.Identifying ligand binding conformations of the β2-adrenergic receptor by using its agonists as computational probesPrincipal component analysis of binding energies for single-point mutants of hT2R16 bound to an agonist correlate with experimental mutant cell responseIn silico analysis of the binding of agonists and blockers to the β2-adrenergic receptor.Agonist binding by the β2-adrenergic receptor: an effect of receptor conformation on ligand association-dissociation characteristicsEffect of fenoterol stereochemistry on the β2 adrenergic receptor system: ligand-directed chiral recognition.Fourier transform microwave spectroscopy of Ac-Ser-NH2: the role of side chain interactions in peptide folding.Multiresidue Method for Analysis of β Agonists in Swine Urine by Enzyme Linked Receptor Assay Based on β2 Adrenergic Receptor Expressed in HEK293 CellsReceptor conformations involved in dopamine D(2L) receptor functional selectivity induced by selected transmembrane-5 serine mutations.Investigation of allosteric coupling in human β2-adrenergic receptor in the presence of intracellular loop 3.Ligand-stabilized conformational states of human beta(2) adrenergic receptor: insight into G-protein-coupled receptor activation.Structure-function of alpha1-adrenergic receptors.Bidirectional, iterative approach to the structural delineation of the functional "chemoprint" in GPR40 for agonist recognition.G protein coupled receptor structure and activationConformational changes in G-protein-coupled receptors-the quest for functionally selective conformations is open.Kinetics of G-protein-coupled receptor signals in intact cellsThe molecular basis of species-specific ligand activation of trace amine-associated receptor 1 (TAAR(1)).Toward deciphering the code to aminergic G protein-coupled receptor drug design.Molecular interactions between fenoterol stereoisomers and derivatives and the β₂-adrenergic receptor binding site studied by docking and molecular dynamics simulations.Distinct evolutionary patterns between chemoreceptors of 2 vertebrate olfactory systems and the differential tuning hypothesis.Biased agonism at G protein-coupled receptors: the promise and the challenges--a medicinal chemistry perspective.Structural signatures of DRD4 mutants revealed using molecular dynamics simulations: Implications for drug targeting.GPCR agonist binding revealed by modeling and crystallography.Stereoselective binding of agonists to the β2-adrenergic receptor: insights into molecular details and thermodynamics from molecular dynamics simulations.Levosalbutamol in the treatment of asthma.
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Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Involvement of Asn-293 in ster ...... he beta 2-adrenergic receptor.
@en
Involvement of Asn-293 in ster ...... he beta 2-adrenergic receptor.
@nl
type
label
Involvement of Asn-293 in ster ...... he beta 2-adrenergic receptor.
@en
Involvement of Asn-293 in ster ...... he beta 2-adrenergic receptor.
@nl
prefLabel
Involvement of Asn-293 in ster ...... he beta 2-adrenergic receptor.
@en
Involvement of Asn-293 in ster ...... he beta 2-adrenergic receptor.
@nl
P2093
P2860
P356
P1476
Involvement of Asn-293 in ster ...... he beta 2-adrenergic receptor.
@en
P2093
P2860
P304
P356
10.1073/PNAS.93.17.9276
P407
P577
1996-08-01T00:00:00Z