Structure-activity relationships of antitubercular nitroimidazoles. 2. Determinants of aerobic activity and quantitative structure-activity relationships.
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Nitroimidazoles for the treatment of TB: past, present and futureStructure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824Pharmacokinetics-pharmacodynamics analysis of bicyclic 4-nitroimidazole analogs in a murine model of tuberculosisAnalysis and hit filtering of a very large library of compounds screened against Mycobacterium tuberculosis.Microwave-assisted synthesis of small molecules targeting the infectious diseases tuberculosis, HIV/AIDS, malaria and hepatitis C.Computational databases, pathway and cheminformatics tools for tuberculosis drug discovery.The effect of 5-substitution on the electrochemical behavior and antitubercular activity of PA-824Syntheses of new tuberculosis inhibitors promoted by microwave irradiationStructure-activity relationships of antitubercular nitroimidazoles. 3. Exploration of the linker and lipophilic tail of ((s)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-(4-trifluoromethoxybenzyl)amine (6-amino PA-824).Discovery and optimization of benzotriazine di-N-oxides targeting replicating and nonreplicating Mycobacterium tuberculosis.Synthesis and evaluation of pretomanid (PA-824) oxazolidinone hybrids.Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesisThe nitroimidazooxazines (PA-824 and analogs): structure-activity relationship and mechanistic studies.Recent advances in the design and synthesis of heterocycles as anti-tubercular agents.Challenges and opportunities in developing novel drugs for TB.Recent advances in the research of heterocyclic compounds as antitubercular agents.The anti-tuberculosis agents under development and the challenges ahead.Synthesis and Biological Evaluation of Polar Functionalities Containing Nitrodihydroimidazooxazoles as Anti-TB AgentsSubstrate specificity of the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis responsible for the bioreductive activation of bicyclic nitroimidazoles.Maximizing bactericidal activity with combinations of bioreduced drugs.An Efficient One-Pot Catalyzed Synthesis of 2,4-Disubstituted 5-Nitroimidazoles Displaying Antiparasitic and Antibacterial Activities.Synthesis of new generation triazolyl- and isoxazolyl-containing 6-nitro-2,3-dihydroimidazooxazoles as anti-TB agents: in vitro, structure-activity relationship, pharmacokinetics and in vivo evaluation.Release of nitrite from the antitubercular nitroimidazole drug PA-824 and analogues upon one-electron reduction in protic, non-aqueous solvent.Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides.Antitubercular Nitroimidazoles Revisited: Synthesis and Activity of the Authentic 3-Nitro Isomer of Pretomanid.Multidirectional Efficacy of Biologically Active Nitro Compounds Included in Medicines.
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Structure-activity relationships of antitubercular nitroimidazoles. 2. Determinants of aerobic activity and quantitative structure-activity relationships.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Structure-activity relationshi ...... ucture-activity relationships.
@en
Structure-activity relationshi ...... ucture-activity relationships.
@nl
type
label
Structure-activity relationshi ...... ucture-activity relationships.
@en
Structure-activity relationshi ...... ucture-activity relationships.
@nl
prefLabel
Structure-activity relationshi ...... ucture-activity relationships.
@en
Structure-activity relationshi ...... ucture-activity relationships.
@nl
P2093
P2860
P50
P356
P1476
Structure-activity relationshi ...... ucture-activity relationships.
@en
P2093
Cynthia S Dowd
Helena I Boshoff
Jan Jiricek
Liang Zhang
Margaret Collins
Michael Goodwin
Pornwaratt Niyomrattanakit
Ramandeep Singh
Sunhee Kang
P2860
P304
P356
10.1021/JM801374T
P407
P577
2009-03-01T00:00:00Z