Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824.
about
Nitroimidazoles for the treatment of TB: past, present and futureDequalinium, a new inhibitor of Mycobacterium tuberculosis mycothiol ligase identified by high-throughput screening.Structure-activity relationships of antitubercular nitroimidazoles. 3. Exploration of the linker and lipophilic tail of ((s)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-(4-trifluoromethoxybenzyl)amine (6-amino PA-824).Carbon-14 radiolabeling and in vivo biodistribution of a potential anti-TB compound.Synthesis and evaluation of pretomanid (PA-824) oxazolidinone hybrids.Quantitative structure-activity relationship studies on nitrofuranyl anti-tubercular agents.Structure-activity relationships of antitubercular nitroimidazoles. 2. Determinants of aerobic activity and quantitative structure-activity relationships.The nitroimidazooxazines (PA-824 and analogs): structure-activity relationship and mechanistic studies.Recent advances in the design and synthesis of heterocycles as anti-tubercular agents.Antituberculosis drug research: a critical overview.PA-824 , moxifloxacin and pyrazinamide combination therapy for tuberculosis.The role of particle physico-chemical properties in pulmonary drug delivery for tuberculosis therapy.Encapsulation of Anti-Tuberculosis Drugs within Mesoporous Silica and Intracellular Antibacterial Activities.Novel Thiazolidinone-Azole Hybrids: Design, Synthesis and Antimycobacterial Activity Studies.Substrate specificity of the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis responsible for the bioreductive activation of bicyclic nitroimidazoles.Maximizing bactericidal activity with combinations of bioreduced drugs.Early diagnosis and effective treatment regimens are the keys to tackle antimicrobial resistance in tuberculosis (TB): A report from Euroscicon's international TB Summit 2016.Carbon-14 radiolabelling and tissue distribution evaluation of a potential anti-TB compound.Total synthesis of the protected aglycon of fidaxomicin (tiacumicin B, lipiarmycin A3).Nitric Oxide in the Pathogenesis and Treatment of Tuberculosis.Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides.Antitubercular Nitroimidazoles Revisited: Synthesis and Activity of the Authentic 3-Nitro Isomer of Pretomanid.Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H-imidazo[2,1- b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis.
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P2860
Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Synthesis and antitubercular a ...... oxazines, analogues of PA-824.
@ast
Synthesis and antitubercular a ...... oxazines, analogues of PA-824.
@en
type
label
Synthesis and antitubercular a ...... oxazines, analogues of PA-824.
@ast
Synthesis and antitubercular a ...... oxazines, analogues of PA-824.
@en
prefLabel
Synthesis and antitubercular a ...... oxazines, analogues of PA-824.
@ast
Synthesis and antitubercular a ...... oxazines, analogues of PA-824.
@en
P2093
P2860
P50
P1476
Synthesis and antitubercular a ...... oxazines, analogues of PA-824.
@en
P2093
Cynthia S Dowd
John E Knox
Michael B Goodwin
Ujjini H Manjunatha
Xiaojin Li
P2860
P304
P356
10.1016/J.BMCL.2008.03.011
P407
P577
2008-03-07T00:00:00Z