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Extinction of hepatitis C virus by ribavirin in hepatoma cells involves lethal mutagenesisNew strategies against drug resistance to herpes simplex virusMerging molecular mechanism and evolution: theory and computation at the interface of biophysics and evolutionary population geneticsDoes mutational robustness inhibit extinction by lethal mutagenesis in viral populations?Stochastic simulations suggest that HIV-1 survives close to its error thresholdQuantitative Modeling of Microbial Population Responses to Chronic Irradiation Combined with Other StressorsContingency and entrenchment in protein evolution under purifying selectionEvolutionary fates within a microbial population highlight an essential role for protein folding during natural selection.Highly expressed and slowly evolving proteins share compositional properties with thermophilic proteinsMutation bias favors protein folding stability in the evolution of small populationsLess can be more: RNA-adapters may enhance coding capacity of replicators.Mutation induced extinction in finite populations: lethal mutagenesis and lethal isolation.The influence of selection for protein stability on dN/dS estimationsEnvironmental dependence of genetic constraint.Synonymous mutations reduce genome compactness in icosahedral ssRNA viruses.A biophysical protein folding model accounts for most mutational fitness effects in viruses.Population size dependence of fitness effect distribution and substitution rate probed by biophysical model of protein thermostability.Bridging the physical scales in evolutionary biology: from protein sequence space to fitness of organisms and populations.Relationship between protein thermodynamic constraints and variation of evolutionary rates among sites.Thermal adaptation of viruses and bacteria.Lethal mutagenesis and evolutionary epidemiologyEvolutionary dynamics of viral escape under antibodies stress: A biophysical model.Virtual genomes in flux: an interplay of neutrality and adaptability explains genome expansion and streamlining.Accelerated simulation of evolutionary trajectories in origin-fixation models.Beyond Thermodynamic Constraints: Evolutionary Sampling Generates Realistic Protein Sequence Variation.Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation.Two sides of the same coin: A population genetics perspective on lethal mutagenesis and mutational meltdown.Evolution models with lethal mutations on symmetric or random fitness landscapes
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 20 July 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Lethal mutagenesis in viruses and bacteria.
@en
Lethal mutagenesis in viruses and bacteria.
@nl
type
label
Lethal mutagenesis in viruses and bacteria.
@en
Lethal mutagenesis in viruses and bacteria.
@nl
prefLabel
Lethal mutagenesis in viruses and bacteria.
@en
Lethal mutagenesis in viruses and bacteria.
@nl
P2860
P1433
P1476
Lethal mutagenesis in viruses and bacteria.
@en
P2093
Peiqiu Chen
P2860
P304
P356
10.1534/GENETICS.109.106492
P407
P577
2009-07-20T00:00:00Z