Limited copy number-high resolution melting (LCN-HRM) enables the detection and identification by sequencing of low level mutations in cancer biopsies
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The implications of heterogeneous DNA methylation for the accurate quantification of methylationUltrasensitive detection of drug-resistant pandemic 2009 (H1N1) influenza A virus by rare-variant-sensitive high-resolution melting-curve analysis.Detection of somatic mutations in tumors using unaligned clonal sequencing data.Intratumoral genetic heterogeneity in metastatic melanoma is accompanied by variation in malignant behaviors.Sequence artefacts in a prospective series of formalin-fixed tumours tested for mutations in hotspot regions by massively parallel sequencing.Comparison of pre-analytical FFPE sample preparation methods and their impact on massively parallel sequencing in routine diagnosticsMassively parallel sequencing fails to detect minor resistant subclones in tissue samples prior to tyrosine kinase inhibitor therapy.High-resolution melting (HRM) re-analysis of a polyposis patients cohort reveals previously undetected heterozygous and mosaic APC gene mutations.Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil- DNA glycosylase.Phylogenomics using formalin-fixed and 100+ year-old intractable natural history specimens.A multisite blinded study for the detection of BRAF mutations in formalin-fixed, paraffin-embedded malignant melanomaMutation profiling of adenoid cystic carcinomas from multiple anatomical sites identifies mutations in the RAS pathway, but no KIT mutations.Targeted-capture massively-parallel sequencing enables robust detection of clinically informative mutations from formalin-fixed tumours.Detection of BRAF mutations in patients with hairy cell leukemia and related lymphoproliferative disordersTouch imprint cytology with massively parallel sequencing (TIC-seq): a simple and rapid method to snapshot genetic alterations in tumorsIncreased sensitivity of KRAS mutation detection by high-resolution melting analysis of COLD-PCR products.Optimized algorithm for Sanger sequencing-based EGFR mutation analyses in NSCLC biopsies.A robust targeted sequencing approach for low input and variable quality DNA from clinical samples.A simple and robust real-time qPCR method for the detection of PIK3CA mutations.A fast, cost-efficient and sensitive approach for KRAS mutation detection using multiplexed primer extension with IP/RP-HPLC separation.Rapid detection of FLT3 exon 20 tyrosine kinase domain mutations in patients with acute myeloid leukemia by high-resolution melting analysis.Predictive Tumor Biomarkers for EGFR Inhibitors
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P2860
Limited copy number-high resolution melting (LCN-HRM) enables the detection and identification by sequencing of low level mutations in cancer biopsies
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 08 October 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Limited copy number-high resol ...... l mutations in cancer biopsies
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Limited copy number-high resolution melting
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type
label
Limited copy number-high resol ...... l mutations in cancer biopsies
@en
Limited copy number-high resolution melting
@nl
prefLabel
Limited copy number-high resol ...... l mutations in cancer biopsies
@en
Limited copy number-high resolution melting
@nl
P2860
P356
P1433
P1476
Limited copy number-high resol ...... l mutations in cancer biopsies
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P2093
P2860
P2888
P356
10.1186/1476-4598-8-82
P577
2009-10-08T00:00:00Z
P5875
P6179
1037892002