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HATL5: a cell surface serine protease differentially expressed in epithelial cancersMatriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndromeStructure of catalytic domain of Matriptase in complex with Sunflower trypsin inhibitor-1Crystal Structures of Matriptase in Complex with Its Inhibitor Hepatocyte Growth Factor Activator Inhibitor-1Development and characterization of new peptidomimetic inhibitors of the West Nile virus NS2B-NS3 proteaseLaminin-332 cleavage by matriptase alters motility parameters of prostate cancer cells.From prediction to experimental validation: desmoglein 2 is a functionally relevant substrate of matriptase in epithelial cells and their reciprocal relationship is important for cell adhesion.Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesisTargeting zymogen activation to control the matriptase-prostasin proteolytic cascade.Proteolytic cleavage of human acid-sensing ion channel 1 by the serine protease matriptaseDiversity of matriptase expression level and function in breast cancer.Combinatorial tuning of peptidic drug candidates: high-affinity matriptase inhibitors through incremental structure-guided optimization.Combinatorial optimization of cystine-knot peptides towards high-affinity inhibitors of human matriptase-1Matriptase deletion initiates a Sjögren's syndrome-like disease in mice.Membrane-anchored serine proteases in health and disease.Cell Surface Human Airway Trypsin-Like Protease Is Lost During Squamous Cell Carcinogenesis.Type II transmembrane serine proteases as potential targets for cancer therapy.Matriptase activation and shedding through PDGF-D-mediated extracellular acidosis.Differential tumorigenic potential and matriptase activation between PDGF B versus PDGF D in prostate cancer.Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis.Matriptase regulates c-Met mediated proliferation and invasion in inflammatory breast cancer.Decreasing the ratio of matriptase/HAI‑1 by downregulation of matriptase as a potential adjuvant therapy in ovarian cancer.Human airway trypsin-like protease, a serine protease involved in respiratory diseases.Roles of Grainyhead-like transcription factors in cancer.Strong expression association between matriptase and its substrate prostasin in breast cancer.Design and synthesis of potent, selective inhibitors of matriptase.Crystal Structure of a Two-domain Fragment of Hepatocyte Growth Factor Activator Inhibitor-1: FUNCTIONAL INTERACTIONS BETWEEN THE KUNITZ-TYPE INHIBITOR DOMAIN-1 AND THE NEIGHBORING POLYCYSTIC KIDNEY DISEASE-LIKE DOMAIN.Limiting the Number of Potential Binding Modes by Introducing Symmetry into Ligands: Structure-Based Design of Inhibitors for Trypsin-Like Serine Proteases.Kempopeptin C, a Novel Marine-Derived Serine Protease Inhibitor Targeting Invasive Breast Cancer.The type II transmembrane serine protease matriptase cleaves the amyloid precursor protein and reduces its processing to β amyloid.Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer.Between two worlds: a comparative study on in vitro and in silico inhibition of trypsin and matriptase by redox-stable SFTI-1 variants at near physiological pH.The Kunitz Domain I of Hepatocyte Growth Factor Activator Inhibitor-2 Inhibits Matriptase Activity and Invasive Ability of Human Prostate Cancer Cells.Design and chemical syntheses of potent matriptase-2 inhibitors based on trypsin inhibitor SFTI-1 isolated from sunflower seeds.Effect of a synthetic inhibitor of urokinase plasminogen activator on the migration and invasion of human cervical cancer cells in vitro.Regulation of matriptase and HAI-1 system, a novel therapeutic target in human endometrial cancer cells.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Matriptase: a culprit in cancer?
@en
Matriptase: a culprit in cancer?
@nl
type
label
Matriptase: a culprit in cancer?
@en
Matriptase: a culprit in cancer?
@nl
prefLabel
Matriptase: a culprit in cancer?
@en
Matriptase: a culprit in cancer?
@nl
P2860
P356
P1433
P1476
Matriptase: a culprit in cancer?
@en
P2093
Karin List
P2860
P304
P356
10.2217/14796694.5.1.97
P407
P577
2009-02-01T00:00:00Z