The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.
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FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylationSLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistanceConserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signalingThe Emerging Role of Branched-Chain Amino Acids in Insulin Resistance and MetabolismAmino Acid Sensing by mTORC1: Intracellular Transporters Mark the SpotAdvances in Autophagy Regulatory MechanismsRegulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glanceAmino acid management in cancerThe molecular basis for load-induced skeletal muscle hypertrophyNutrient-sensing mechanisms across evolutionRegulation of mTORC1 by amino acidsThe expanding role of mTOR in cancer cell growth and proliferationFolliculin regulates ampk-dependent autophagy and metabolic stress survivalExpression and knockdown of zebrafish folliculin suggests requirement for embryonic brain morphogenesis.Response and acquired resistance to everolimus in anaplastic thyroid cancerReciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy.Genomic Analysis of ATP Efflux in Saccharomyces cerevisiae.Transcriptional and epigenetic regulation of autophagy in agingBeyond indigestion: emerging roles for lysosome-based signaling in human diseaseStructural basis for leucine sensing by the Sestrin2-mTORC1 pathwaySestrin2 is a leucine sensor for the mTORC1 pathwayThe Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signalingThe CASTOR Proteins Are Arginine Sensors for the mTORC1 PathwayA genome-wide siRNA screen in mammalian cells for regulators of S6 phosphorylationmTOR signaling in tumorigenesisWhere is mTOR and what is it doing there?Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell deathKICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB SignalingC9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling.The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond.Loss of hepatic DEPTOR alters the metabolic transition to fastingTopical rapamycin as a treatment for fibrofolliculomas in Birt-Hogg-Dubé syndrome: a double-blind placebo-controlled randomized split-face trial.Negative regulation of EGFR signalling by the human folliculin tumour suppressor proteinmTOR and lysosome regulation.Skeletal muscle Ras-related GTP binding B mRNA and protein expression is increased after essential amino acid ingestion in healthy humansFolliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulation
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The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 03 October 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The folliculin tumor suppresso ...... l amino acid levels to mTORC1.
@en
The folliculin tumor suppresso ...... l amino acid levels to mTORC1.
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type
label
The folliculin tumor suppresso ...... l amino acid levels to mTORC1.
@en
The folliculin tumor suppresso ...... l amino acid levels to mTORC1.
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prefLabel
The folliculin tumor suppresso ...... l amino acid levels to mTORC1.
@en
The folliculin tumor suppresso ...... l amino acid levels to mTORC1.
@nl
P2093
P2860
P921
P1433
P1476
The folliculin tumor suppresso ...... l amino acid levels to mTORC1.
@en
P2093
Eric Spooner
Liron Bar-Peled
Lynne Chantranupong
Roberto Zoncu
Zhi-Yang Tsun
P2860
P304
P356
10.1016/J.MOLCEL.2013.09.016
P577
2013-10-03T00:00:00Z