The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain. - Wikidata - awgldk - TriplyDB

The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain.

The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain.

http://www.wikidata.org/entity/Q37402856

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USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1 An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma XLID-causing mutations and associated genes challenged in light of data from large-scale human exome sequencing The role of targeted protein degradation in early neural development Molecular control of neurogenesis: a view from the mammalian cerebral cortex Interrogation of a context-specific transcription factor network identifies novel regulators of pluripotency Bagging statistical network inference from large-scale gene expression data A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets Dynamic interactions between intermediate neurogenic progenitors and radial glia in embryonic mouse neocortex: potential role in Dll1-Notch signaling Leveraging models of cell regulation and GWAS data in integrative network-based association studies Copy-number gains of HUWE1 due to replication- and recombination-based rearrangements Prioritizing the development of mouse models for childhood brain disorders hARACNe: improving the accuracy of regulatory model reverse engineering via higher-order data processing inequality tests.Inferring protein modulation from gene expression data using conditional mutual information.The transcriptional network for mesenchymal transformation of brain tumours.E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration Primary brain tumors, neural stem cell, and brain tumor cancer cells: where is the link?Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum Homeostatic defects in B cells deficient in the E3 ubiquitin ligase ARF-BP1 are restored by enhanced expression of MYC c-myc and N-myc promote active stem cell metabolism and cycling as architects of the developing brain.Reverse-engineering human regulatory networks Destroy to create: E3 ubiquitin ligases in neurogenesis.Novel multi-nucleotide polymorphisms in the human genome characterized by whole genome and exome sequencing.Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development.HUWE1 is a molecular link controlling RAF-1 activity supported by the Shoc2 scaffold.Identification of causal genetic drivers of human disease through systems-level analysis of regulatory networks.Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.c- and N-myc regulate neural precursor cell fate, cell cycle, and metabolism to direct cerebellar development.Targeting Notch pathway induces growth inhibition and differentiation of neuroblastoma cells.Comparative genomics using teleost fish helps to systematically identify target gene bodies of functionally defined human enhancers.Ubiquitin ligase HUWE1 regulates axon branching through the Wnt/β-catenin pathway in a Drosophila model for intellectual disability.Cell biological regulation of division fate in vertebrate neuroepithelial cells.Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase Tipping the MYC-MIZ1 balance: targeting the HUWE1 ubiquitin ligase selectively blocks MYC-activated genes.Identifying candidate drivers of alcohol dependence-induced excessive drinking by assembly and interrogation of brain-specific regulatory networks Using systems and structure biology tools to dissect cellular phenotypes Inactivation of arf-bp1 induces p53 activation and diabetic phenotypes in mice.Novel miRNA-31 and miRNA-200a-Mediated Regulation of Retinoblastoma Proliferation Paracrine signaling through MYCN enhances tumor-vascular interactions in neuroblastoma.Notch ligand Delta-like 1 as a novel molecular target in childhood neuroblastoma

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The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain.

http://www.wikidata.org/entity/Q37402856

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on August 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

The N-Myc-DLL3 cascade is supp ...... nesis in the developing brain.

@en

The N-Myc-DLL3 cascade is supp ...... nesis in the developing brain.

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type

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The N-Myc-DLL3 cascade is supp ...... nesis in the developing brain.

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The N-Myc-DLL3 cascade is supp ...... nesis in the developing brain.

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prefLabel

The N-Myc-DLL3 cascade is supp ...... nesis in the developing brain.

@en

The N-Myc-DLL3 cascade is supp ...... nesis in the developing brain.

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J.DEVCEL.2009.07.009

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Developmental Cell

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The N-Myc-DLL3 cascade is supp ...... enesis in the developing brain

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Carlos Cordon Cardo

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Francois Guillemot

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Ken Aldape

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Manisha Brahmachary

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Thomas Ludwig

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Wei Keat Lim

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Xudong Zhao

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P2860

Characterization of E3Histone, a novel testis ubiquitin protein ligase which ubiquitinates histones.

ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells

Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade

N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation

The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation

The cell biology of neurogenesis

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210-221

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scholarly article

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10.1016/J.DEVCEL.2009.07.009

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2

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17

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Andrea Califano

Domenico D'Arca

Maria Stella Carro

Antonio Iavarone

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2009-08-01T00:00:00Z

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26747753

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19686682

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