Application of the Goldilocks effect to the design of potent and selective inhibitors of phenylethanolamine N-methyltransferase: balancing pKa and steric effects in the optimization of 3-methyl-1,2,3,4-tetrahydroisoquinoline inhibitors by beta-fluor - Wikidata - awgldk - TriplyDB

Application of the Goldilocks effect to the design of potent and selective inhibitors of phenylethanolamine N-methyltransferase: balancing pKa and steric effects in the optimization of 3-methyl-1,2,3,4-tetrahydroisoquinoline inhibitors by beta-fluor

Application of the Goldilocks effect to the design of potent and selective inhibitors of phenylethanolamine N-methyltransferase: balancing pKa and steric effects in the optimization of 3-methyl-1,2,3,4-tetrahydroisoquinoline inhibitors by beta-fluor

http://www.wikidata.org/entity/Q37406616

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Fluoro-substituted ketones from nitriles using acidic and basic reaction conditions A beta-fluoroamine inhibitor of purine nucleoside phosphorylase Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase.Introduction of fluorine and fluorine-containing functional groups.Synthesis of Aryldifluoroamides by Copper-Catalyzed Cross-Coupling.The Goldilocks principle in action: synthesis and structural characterization of a novel {Cu4(μ3-OH)4} cubane stabilized by monodentate ligands.pH Effect and Chemical Mechanisms of Antioxidant Higenamine

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P2860

Application of the Goldilocks effect to the design of potent and selective inhibitors of phenylethanolamine N-methyltransferase: balancing pKa and steric effects in the optimization of 3-methyl-1,2,3,4-tetrahydroisoquinoline inhibitors by beta-fluor

http://www.wikidata.org/entity/Q37406616

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on May 2006

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

Application of the Goldilocks ...... oline inhibitors by beta-fluor

@en

Application of the Goldilocks ...... oline inhibitors by beta-fluor

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type

label

Application of the Goldilocks ...... oline inhibitors by beta-fluor

@en

Application of the Goldilocks ...... oline inhibitors by beta-fluor

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prefLabel

Application of the Goldilocks ...... oline inhibitors by beta-fluor

@en

Application of the Goldilocks ...... oline inhibitors by beta-fluor

@nl

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Journal of Medicinal Chemistry

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Application of the Goldilocks ...... oline inhibitors by beta-fluor

@en

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Gary L Grunewald

http://www.w3.org/2001/XMLSchema#string

Jian Lu

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Kevin R Criscione

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Mariam Makboul

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Mitchell R Seim

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Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase.

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2939-2952

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scholarly article

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10.1021/JM051262K

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10

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7093871

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16686536

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2770873

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