Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.
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Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stressInhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutationLRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2The role of oxidative stress in Parkinson's diseaseRAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease riskThiol peroxidases ameliorate LRRK2 mutant-induced mitochondrial and dopaminergic neuronal degeneration in DrosophilaDysregulated LRRK2 signaling in response to endoplasmic reticulum stress leads to dopaminergic neuron degeneration in C. elegansLeucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like proteinMutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neuronsEvaluation of Models of Parkinson's DiseaseHeterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implicationsThe role of the LRRK2 gene in ParkinsonismProgressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in miceMechanisms of aging-related proteinopathies in Caenorhabditis elegansGene-environment interactions: key to unraveling the mystery of Parkinson's diseaseEnhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019SDisease-toxicant interactions in Parkinson's disease neuropathologyGTPase activity plays a key role in the pathobiology of LRRK2.Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).Parkinson's disease: insights from pathways.Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models.Drosophila melanogaster in the study of human neurodegeneration.Neurodegenerative models in Drosophila: polyglutamine disorders, Parkinson disease, and amyotrophic lateral sclerosis.RNA metabolism in the pathogenesis of Parkinson׳s diseaseRole of LRRK2 kinase dysfunction in Parkinson diseaseCinnamon treatment upregulates neuroprotective proteins Parkin and DJ-1 and protects dopaminergic neurons in a mouse model of Parkinson's disease.In vivo evidence of pathogenicity of VPS35 mutations in the Drosophila.The dopaminergic system in the aging brain of Drosophila.Modeling neurodegeneration in zebrafishDrosophila models of Parkinson's disease: discovering relevant pathways and novel therapeutic strategies.Gene-environment interactions in Parkinson's disease: the importance of animal modeling.Models for LRRK2-Linked Parkinsonism.Can cinnamon bring aroma in Parkinson's disease treatment?Ubiquitination in postsynaptic function and plasticityThe Parkinson's disease protein LRRK2 impairs proteasome substrate clearance without affecting proteasome catalytic activity.Oxidative stress and brain mitochondria swelling induced by endosulfan and protective role of quercetin in rat.Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease.Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological processes modulated by LRRK2 activity.
P2860
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P2860
Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Parkin protects against LRRK2 ...... urodegeneration in Drosophila.
@en
Parkin protects against LRRK2 ...... urodegeneration in Drosophila.
@nl
type
label
Parkin protects against LRRK2 ...... urodegeneration in Drosophila.
@en
Parkin protects against LRRK2 ...... urodegeneration in Drosophila.
@nl
prefLabel
Parkin protects against LRRK2 ...... urodegeneration in Drosophila.
@en
Parkin protects against LRRK2 ...... urodegeneration in Drosophila.
@nl
P2093
P2860
P50
P1476
Parkin protects against LRRK2 ...... eurodegeneration in Drosophila
@en
P2093
Cherlyn Koh
Eng-King Tan
Kah-Leong Lim
Shaun Z S Mok
Ted M Dawson
Valina L Dawson
Xuezhi Ouyang
P2860
P304
11257-11262
P356
10.1523/JNEUROSCI.2375-09.2009
P407
P577
2009-09-01T00:00:00Z