Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
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Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation updateThe Parkinson disease-linked LRRK2 protein mutation I2020T stabilizes an active state conformation leading to increased kinase activityPathogenic LRRK2 negatively regulates microRNA-mediated translational repressionLeucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADPLRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stressExpression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model systemMKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutationBiochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimersLRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complexLRRK2 and the stress response: interaction with MKKs and JNK-interacting proteinsLRRK2 kinase activity and biology are not uniformly predicted by its autophosphorylation and cellular phosphorylation site statusIdentification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screenLRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1Identification of potential protein interactors of Lrrk2The R1441C mutation of LRRK2 disrupts GTP hydrolysisLeucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi exportLRRK2 interactions with α-synuclein in Parkinson's disease brains and in cell modelsARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutationsLRRK2 transport is regulated by its novel interacting partner Rab32Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibitionLRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: a morphological and quantitative studyArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagyThe role of oxidative stress in Parkinson's diseaseFunctional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamilyParkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylationLRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junctionIdentification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycleLRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodiesThe Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylationThiol peroxidases ameliorate LRRK2 mutant-induced mitochondrial and dopaminergic neuronal degeneration in DrosophilaInterplay of LRRK2 with chaperone-mediated autophagyThe Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration
P2860
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P2860
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
description
2005 nî lūn-bûn
@nan
2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Parkinson's disease-associated ...... nase 2 augment kinase activity
@ast
Parkinson's disease-associated ...... nase 2 augment kinase activity
@en
Parkinson's disease-associated ...... nase 2 augment kinase activity
@en-gb
Parkinson's disease-associated ...... nase 2 augment kinase activity
@nl
type
label
Parkinson's disease-associated ...... nase 2 augment kinase activity
@ast
Parkinson's disease-associated ...... nase 2 augment kinase activity
@en
Parkinson's disease-associated ...... nase 2 augment kinase activity
@en-gb
Parkinson's disease-associated ...... nase 2 augment kinase activity
@nl
prefLabel
Parkinson's disease-associated ...... nase 2 augment kinase activity
@ast
Parkinson's disease-associated ...... nase 2 augment kinase activity
@en
Parkinson's disease-associated ...... nase 2 augment kinase activity
@en-gb
Parkinson's disease-associated ...... nase 2 augment kinase activity
@nl
P2093
P2860
P921
P3181
P356
P1476
Parkinson's disease-associated ...... nase 2 augment kinase activity
@en
P2093
Andrew B West
Artem Bugayenko
Darren J Moore
Saskia Biskup
Valina L Dawson
Wanli W Smith
P2860
P304
P356
10.1073/PNAS.0507360102
P407
P577
2005-11-15T00:00:00Z