Targeted disruption of peptide transporter Pept1 gene in mice significantly reduces dipeptide absorption in intestine
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Inflammation Meets Metabolic Disease: Gut Feeling Mediated by GLP-1Intestinal organoids for assessing nutrient transport, sensing and incretin secretionThe intestinal peptide transporter PEPT1 is involved in food intake regulation in mice fed a high-protein dietPutative anion transporter-1 (Pat-1, Slc26a6) contributes to intracellular pH regulation during H+-dipeptide transport in duodenal villous epitheliumGene ablation for PEPT1 in mice abolishes the effects of dipeptides on small intestinal fluid absorption, short-circuit current, and intracellular pH.Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Amino acid absorption and homeostasis in mice lacking the intestinal peptide transporter PEPT1.RGS4, a GTPase activator, improves renal function in ischemia-reperfusion injury.Significance and regional dependency of peptide transporter (PEPT) 1 in the intestinal permeability of glycylsarcosine: in situ single-pass perfusion studies in wild-type and Pept1 knockout miceDevelopment and characterization of a novel mouse line humanized for the intestinal peptide transporter PEPT1The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics.Peptide transporter 1 is responsible for intestinal uptake of the dipeptide glycylsarcosine: studies in everted jejunal rings from wild-type and Pept1 null miceMice lacking the intestinal peptide transporter display reduced energy intake and a subtle maldigestion/malabsorption that protects them from diet-induced obesity.The peptide transporter PEPT1 is expressed in distal colon in rodents and humans and contributes to water absorption.Peptide transport and animal growth: the fish paradigmColonic expression of the peptide transporter PEPT1 is downregulated during intestinal inflammation and is not required for NOD2-dependent immune activation.Effect of dose escalation on the in vivo oral absorption and disposition of glycylsarcosine in wild-type and Pept1 knockout mice.Influence of fed-fasted state on intestinal PEPT1 expression and in vivo pharmacokinetics of glycylsarcosine in wild-type and Pept1 knockout mice.Effect of N-glycosylation on the transport activity of the peptide transporter PEPT1.Species-dependent uptake of glycylsarcosine but not oseltamivir in Pichia pastoris expressing the rat, mouse, and human intestinal peptide transporter PEPT1.Significance of peptide transporter 1 in the intestinal permeability of valacyclovir in wild-type and PepT1 knockout mice.Relevance of PepT1 in the intestinal permeability and oral absorption of cefadroxilProton-coupled oligopeptide transporter family SLC15: physiological, pharmacological and pathological implications.The proton-coupled oligopeptide transporter 1 plays a major role in the intestinal permeability and absorption of 5-aminolevulinic acidSpecies differences in the pharmacokinetics of cefadroxil as determined in wildtype and humanized PepT1 miceFunctional and molecular expression of the proton-coupled oligopeptide transporters in spleen and macrophages from mouse and humanImpact of peptide transporter 1 on the intestinal absorption and pharmacokinetics of valacyclovir after oral dose escalation in wild-type and PepT1 knockout mice.Influence of genetic knockout of Pept2 on the in vivo disposition of endogenous and exogenous carnosine in wild-type and Pept2 null mice.Impact of intestinal PepT1 on the kinetics and dynamics of N-formyl-methionyl-leucyl-phenylalanine, a bacterially-produced chemotactic peptide.In vivo absorption and disposition of cefadroxil after escalating oral doses in wild-type and PepT1 knockout mice.Transport of drugs by proton-coupled peptide transporters: pearls and pitfalls.Nerveless and gutsy: intestinal nutrient sensing from invertebrates to humans.Emerging transporters of clinical importance: an update from the International Transporter Consortium.Transcriptional and functional regulation of the intestinal peptide transporter PEPT1.Transport of amino acids in the kidney.Intestinal barrier dysfunction: implications for chronic inflammatory conditions of the bowel.Di- and tripeptide transport in vertebrates: the contribution of teleost fish models.Role of drug efflux and uptake transporters in atazanavir intestinal permeability and drug-drug interactions.Clathrin- and dynamin-dependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activationAlanyl-glutamine but not glycyl-glutamine improved the proliferation of enterocytes as glutamine substitution in vitro.
P2860
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P2860
Targeted disruption of peptide transporter Pept1 gene in mice significantly reduces dipeptide absorption in intestine
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Targeted disruption of peptide ...... eptide absorption in intestine
@en
Targeted disruption of peptide ...... ptide absorption in intestine.
@nl
type
label
Targeted disruption of peptide ...... eptide absorption in intestine
@en
Targeted disruption of peptide ...... ptide absorption in intestine.
@nl
prefLabel
Targeted disruption of peptide ...... eptide absorption in intestine
@en
Targeted disruption of peptide ...... ptide absorption in intestine.
@nl
P2093
P2860
P356
P1476
Targeted disruption of peptide ...... eptide absorption in intestine
@en
P2093
David E Smith
Dilara Jappar
Kathleen M Hillgren
Winston Thomas
P2860
P304
P356
10.1021/MP8001655
P407
P577
2008-11-01T00:00:00Z