MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL.
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Bone marrow microenvironment-derived signals induce Mcl-1 dependence in multiple myeloma.Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo.The life and death of immune cell types: the role of BCL-2 anti-apoptotic molecules.Heterogeneous Nuclear Ribonucleoprotein A2B1 Exerts a Regulatory Role in Lipopolysaccharide-stimulated 38B9 B Cell Activation.The combination of reduced MCL-1 and standard chemotherapeutics is tolerable in mice.Targeting BCL-2 regulated apoptosis in cancer.SYK Inhibition Induces Apoptosis in Germinal Center-Like B Cells by Modulating the Antiapoptotic Protein Myeloid Cell Leukemia-1, Affecting B-Cell Activation and Antibody Production.Potent anti-leukemic activity of a specific cyclin-dependent kinase 9 inhibitor in mouse models of chronic lymphocytic leukemia.
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MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 25 August 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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MCL-1 is required throughout B ...... inhibition of BCL-2 or BCL-XL.
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MCL-1 is required throughout B ...... inhibition of BCL-2 or BCL-XL.
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type
label
MCL-1 is required throughout B ...... inhibition of BCL-2 or BCL-XL.
@en
MCL-1 is required throughout B ...... inhibition of BCL-2 or BCL-XL.
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prefLabel
MCL-1 is required throughout B ...... inhibition of BCL-2 or BCL-XL.
@en
MCL-1 is required throughout B ...... inhibition of BCL-2 or BCL-XL.
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P2093
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P1476
MCL-1 is required throughout B ...... inhibition of BCL-2 or BCL-XL.
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Anne Slomp
Catherine Chang
Emma M Carrington
Gemma L Kelly
Ingela B Vikström
J H Marco Jansen
Laura M Moesbergen
Stefan P Glaser
Victor Peperzak
P2860
P356
10.1038/CDDIS.2016.237
P577
2016-08-25T00:00:00Z