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Inhibition of the B cell by CD22: a requirement for LynSustained activation of Lyn tyrosine kinase in vivo leads to autoimmunityMultiple routes to B-cell memoryHomeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the visceraArchitectural defects in the spleens of Nkx2-3-deficient mice are intrinsic and associated with defects in both B cell maturation and T cell-dependent immune responsesLyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunityMcl-1 is essential for the survival of plasma cells.The BTB-ZF transcription factor Zbtb20 is driven by Irf4 to promote plasma cell differentiation and longevity.IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism.FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigenRegulation of germinal center responses and B-cell memory by the chromatin modifier MOZBH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs.Single cell sorting and cloning.The combined absence of NF-kappa B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells.Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma developmentIKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen.The tetraspanin CD37 orchestrates the α(4)β(1) integrin-Akt signaling axis and supports long-lived plasma cell survival.Mcl-1 is essential for germinal center formation and B cell memoryThe transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation.The generation of antibody-secreting plasma cells.Generation and analysis of Siah2 mutant mice.B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cellsProsurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cellsRegulation of memory B-cell survival by the BH3-only protein Puma.c-Myb is required for plasma cell migration to bone marrow after immunization or infectionThe Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim.B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cellsDefective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantationLoss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells.bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cellsEarly appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization.SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function.Dynamic changes in Id3 and E-protein activity orchestrate germinal center and plasma cell development.Evolution in miniature: selection, survival and distribution of antigen reactive cells in the germinal centre.Plasma cell development: from B-cell subsets to long-term survival niches.MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL.Memory B cells: effectors of long-lived immune responses.Plasma cell development and survival.
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description
researcher
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wetenschapper
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հետազոտող
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David M Tarlinton
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David M Tarlinton
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David M Tarlinton
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David M Tarlinton
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David M Tarlinton
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David M Tarlinton
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David M Tarlinton
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David M Tarlinton
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David Tarlinton
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Tarlinton DM
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David M Tarlinton
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David M Tarlinton
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David M Tarlinton
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David M Tarlinton
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P106
P21
P31
P496
0000-0001-9928-686X