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Computational enzyme design approaches with significant biological outcomes: progress and challengesFundamental challenges in mechanistic enzymology: progress toward understanding the rate enhancements of enzymesDe novo computational design of retro-aldol enzymesDesign and engineering of an O(2) transport proteinProtein design: toward functional metalloenzymesIdentifying important structural characteristics of arsenic resistance proteins by using designed three-stranded coiled coilsSolution NMR Structure of a Designed Metalloprotein and Complementary Molecular Dynamics RefinementTesting Geometrical Discrimination within an Enzyme Active Site: Constrained Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion HoleStructural Basis for Exquisite Specificity of Affinity Clamps, Synthetic Binding Proteins Generated through Directed Domain-interface EvolutionComputational design of ligand binding is not a solved problemRational design of a structural and functional nitric oxide reductaseMetal templated design of protein interfacesDissecting the paradoxical effects of hydrogen bond mutations in the ketosteroid isomerase oxyanion holeRoles of glutamates and metal ions in a rationally designed nitric oxide reductase based on myoglobinIntroducing a 2-His-1-Glu Nonheme Iron Center into Myoglobin Confers Nitric Oxide Reductase ActivityStructural Comparisons of Apo- and Metalated Three-Stranded Coiled Coils Clarify Metal Binding Determinants in Thiolate Containing Designed PeptidesComputational design of an endo-1,4- -xylanase ligand binding siteDesign of a switchable eliminaseComputational Design of Virus-Like Protein Assemblies on Carbon Nanotube SurfacesPrinciples for designing ideal protein structuresStructure and dynamics of a primordial catalytic fold generated by in vitro evolutionHydrolytic catalysis and structural stabilization in a designed metalloproteinInstalling hydrolytic activity into a completely de novo protein frameworkHigh-precision, in vitro validation of the sequestration mechanism for generating ultrasensitive dose-response curves in regulatory networksThermal, chemical and pH induced denaturation of a multimeric β-galactosidase reveals multiple unfolding pathwaysChemical and thermal unfolding of a global staphylococcal virulence regulator with a flexible C-terminal endCorrelating Calmodulin Landscapes with Chemical Catalysis in Neuronal Nitric Oxide Synthase using Time-Resolved FRET and a 5-Deazaflavin Thermodynamic TrapArtificial Diiron Enzymes with a De Novo Designed Four-Helix Bundle StructureDesigned metalloprotein stabilizes a semiquinone radicalEngineering a zinc binding site into the de novo designed protein DS119 with a βαβ structureDesigning hydrolytic zinc metalloenzymesComputational approaches for rational design of proteins with novel functionalitiesOptGraft: A computational procedure for transferring a binding site onto an existing protein scaffold.The Framework of Computational Protein Design.Achievements and Challenges in Computational Protein Design.Designing artificial enzymes by intuition and computationPeroxidase activity of de novo heme proteins immobilized on electrodes.Selection and structural analysis of de novo proteins from an alpha3beta3 genetic library.Synthetic biology approaches in drug discovery and pharmaceutical biotechnology.Protein thermostability calculations using alchemical free energy simulations
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 03 August 2004
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
De novo design of catalytic proteins.
@en
De novo design of catalytic proteins.
@nl
type
label
De novo design of catalytic proteins.
@en
De novo design of catalytic proteins.
@nl
prefLabel
De novo design of catalytic proteins.
@en
De novo design of catalytic proteins.
@nl
P2860
P356
P1476
De novo design of catalytic proteins.
@en
P2093
P2860
P304
11566-11570
P356
10.1073/PNAS.0404387101
P407
P577
2004-08-03T00:00:00Z