Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse model.
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The FGF23-Klotho axis: endocrine regulation of phosphate homeostasisAlpha Klotho and phosphate homeostasisExploring mechanisms of FGF signalling through the lens of structural biologyDeletion of PTH rescues skeletal abnormalities and high osteopontin levels in Klotho-/- miceKlotho and phosphate are modulators of pathologic uremic cardiac remodeling.From "Kidneys Govern Bones" to Chronic Kidney Disease, Diabetes Mellitus, and Metabolic Bone Disorder: A Crosstalk between Traditional Chinese Medicine and Modern ScienceDysregulation of phosphate metabolism and conditions associated with phosphate toxicityInadequate awareness among chronic kidney disease patients regarding food and drinks containing artificially added phosphatePTHrP(1-34)-mediated repression of the PHEX gene in osteoblastic cells involves the transcriptional repressor E4BP4Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolismIn vivo genetic evidence for suppressing vascular and soft-tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-dihydroxyvitamin d levelsIsolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation.Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging.Heat shock protein 47: a novel biomarker of phenotypically altered collagen-producing cells.Dietary and genetic evidence for enhancing glucose metabolism and reducing obesity by inhibiting klotho functionsOsteo-renal regulation of systemic phosphate metabolism.The dualistic role of vitamin D in vascular calcificationsPhosphate toxicity: new insights into an old problemMolecular regulation of phosphate metabolism by fibroblast growth factor-23-klotho systemFGF-23/Klotho signaling is not essential for the phosphaturic and anabolic functions of PTH.Kbus/Idr, a mutant mouse strain with skeletal abnormalities and hypophosphatemia: identification as an allele of 'Hyp'.Role of Klotho in aging, phosphate metabolism, and CKD.Molecular basis of Klotho: from gene to function in agingPhosphate Metabolism in Cardiorenal Metabolic Disease.Correlates and Longitudinal Renal and Cardiovascular Implications of FGF23 Levels in HIV-Positive Individuals.Conversion of a paracrine fibroblast growth factor into an endocrine fibroblast growth factor.Hexa-D-arginine treatment increases 7B2•PC2 activity in hyp-mouse osteoblasts and rescues the HYP phenotype.Fibroblast growth factors, old kids on the new block.Genetic induction of phosphate toxicity significantly reduces the survival of hypercholesterolemic obese miceThe role of Klotho in energy metabolism.High levels of serum vitamin D are associated with a decreased risk of metabolic diseases in both men and women, but an increased risk for coronary artery calcification in Korean men.Can features of phosphate toxicity appear in normophosphatemia?Can salivary phosphate levels be an early biomarker to monitor the evolvement of obesity?Phosphate homeostasis and the renal-gastrointestinal axis.Disorders of phosphorus homeostasis.Tooth dentin defects reflect genetic disorders affecting bone mineralization.The importance of klotho in phosphate metabolism and kidney disease.Vitamin D in patients with chronic kidney disease: a position statement of the Working Group "Trace Elements and Mineral Metabolism" of the Italian Society of Nephrology.Molecular interactions of FGF23 and PTH in phosphate regulation.Ablation of systemic phosphate-regulating gene fibroblast growth factor 23 (Fgf23) compromises the dentoalveolar complex.
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Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse model.
description
article científic
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article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 07 July 2009
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Inactivation of klotho functio ...... hosphatemic (Hyp) mouse model.
@en
Inactivation of klotho functio ...... ly engineered hypophosphatemic
@nl
type
label
Inactivation of klotho functio ...... hosphatemic (Hyp) mouse model.
@en
Inactivation of klotho functio ...... ly engineered hypophosphatemic
@nl
prefLabel
Inactivation of klotho functio ...... hosphatemic (Hyp) mouse model.
@en
Inactivation of klotho functio ...... ly engineered hypophosphatemic
@nl
P2093
P2860
P356
P1433
P1476
Inactivation of klotho functio ...... hosphatemic (Hyp) mouse model.
@en
P2093
M Shawkat Razzaque
Mutsuko Ohnishi
Teruyo Nakatani
P2860
P304
P356
10.1096/FJ.08-123992
P407
P577
2009-07-07T00:00:00Z