Spatiotemporally separable Shh domains in the midbrain define distinct dopaminergic progenitor pools.
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Sonic hedgehog signaling in the development of the mouse hypothalamusMesencephalic origin of the rostral Substantia nigra pars reticulata.Wnt/β-catenin signaling in midbrain dopaminergic neuron specification and neurogenesis.Common pitfalls of stem cell differentiation: a guide to improving protocols for neurodegenerative disease models and researchMolecular organization and timing of Wnt1 expression define cohorts of midbrain dopamine neuron progenitors in vivoMesodiencephalic dopaminergic neuronal differentiation does not involve GLI2A-mediated SHH-signaling and is under the direct influence of canonical WNT signaling.Embryonic development of selectively vulnerable neurons in Parkinson's disease.Sonic hedgehog expressing and responding cells generate neuronal diversity in the medial amygdala.Tracing lineages to uncover neuronal identity.Ectopic Wnt/beta-catenin signaling induces neurogenesis in the spinal cord and hindbrain floor plate.Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance.Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid.CDO, an Hh-coreceptor, mediates lung cancer cell proliferation and tumorigenicity through Hedgehog signalingLeptin signaling modulates the activity of urocortin 1 neurons in the mouse nonpreganglionic Edinger-Westphal nucleus.Defining midbrain dopaminergic neuron diversity by single-cell gene expression profiling.Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitorsMolecular marker differences relate to developmental position and subsets of mesodiencephalic dopaminergic neurons.An Lmx1b-miR135a2 regulatory circuit modulates Wnt1/Wnt signaling and determines the size of the midbrain dopaminergic progenitor pool.Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei.Timing of Sonic hedgehog and Gli1 expression segregates midbrain dopamine neurons.Sonic hedgehog lineage in the mouse hypothalamus: from progenitor domains to hypothalamic regions.Organotypic slice cultures of embryonic ventral midbrain: a system to study dopaminergic neuronal development in vitro.Excessive Wnt/beta-catenin signaling promotes midbrain floor plate neurogenesis, but results in vacillating dopamine progenitors.Molecular heterogeneity of midbrain dopaminergic neurons--Moving toward single cell resolution.Duration of Shh signaling contributes to mDA neuron diversityDynamic temporal requirement of Wnt1 in midbrain dopamine neuron development.Temporal and spatial requirements of Smoothened in ventral midbrain neuronal developmentGenetic control of midbrain dopaminergic neuron development.Functional Interplay between Dopaminergic and Serotonergic Neuronal Systems during Development and Adulthood.Establishing diversity in the dopaminergic system.Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b.Neuronal Subset-Specific Migration and Axonal Wiring Mechanisms in the Developing Midbrain Dopamine System.Dopaminergic Neurons and Brain Reward Pathways: From Neurogenesis to Circuit Assembly.Expression patterns of key Sonic Hedgehog signaling pathway components in the developing and adult mouse midbrain and in the MN9D cell line.Nato3 integrates with the Shh-Foxa2 transcriptional network regulating the differentiation of midbrain dopaminergic neurons.Lmx1a allows context-specific isolation of progenitors of GABAergic or dopaminergic neurons during neural differentiation of embryonic stem cells.Expression of early developmental markers predicts the efficiency of embryonic stem cell differentiation into midbrain dopaminergic neurons.GABAergic and glutamatergic identities of developing midbrain Pitx2 neurons.Making a mes: A transcription factor-microRNA pair governs the size of the midbrain and the dopaminergic progenitor pool.A novel role for FOXA2 and SHH in organizing midbrain signaling centers.
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Spatiotemporally separable Shh domains in the midbrain define distinct dopaminergic progenitor pools.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 22 October 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Spatiotemporally separable Shh ...... dopaminergic progenitor pools.
@en
Spatiotemporally separable Shh ...... dopaminergic progenitor pools.
@nl
type
label
Spatiotemporally separable Shh ...... dopaminergic progenitor pools.
@en
Spatiotemporally separable Shh ...... dopaminergic progenitor pools.
@nl
prefLabel
Spatiotemporally separable Shh ...... dopaminergic progenitor pools.
@en
Spatiotemporally separable Shh ...... dopaminergic progenitor pools.
@nl
P2093
P2860
P356
P1476
Spatiotemporally separable Shh ...... dopaminergic progenitor pools.
@en
P2093
Angela Anderegg
Laura Campochiaro
Milan Joksimovic
Raja Kittappa
Rajeshwar Awatramani
Ronald McKay
P2860
P304
19185-19190
P356
10.1073/PNAS.0904285106
P407
P577
2009-10-22T00:00:00Z