PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1. - Wikidata - awgldk - TriplyDB

PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1.

PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1.

http://www.wikidata.org/entity/Q37421358

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PI3K and AKT: Unfaithful Partners in Cancer Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer Deciphering the link between PI3K and PAK: An opportunity to target key pathways in pancreatic cancer?Regulation and function of P-Rex family Rac-GEFs Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor Context Sensitive Modeling of Cancer Drug Sensitivity Control of developmental networks by Rac/Rho small GTPases: How cytoskeletal changes during embryogenesis are orchestrated Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas Arpin downregulation in breast cancer is associated with poor prognosis.Transmigration characteristics of breast cancer and melanoma cells through the brain endothelium: Role of Rac and PI3K.Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer Rational combination of dual PI3K/mTOR blockade and Bcl-2/-xL inhibition in AML.P-Rex1 Expression in Invasive Breast Cancer in relation to Receptor Status and Distant Metastatic Site.Membrane progesterone receptor beta (mPRβ/Paqr8) promotes progesterone-dependent neurite outgrowth in PC12 neuronal cells via non-G protein-coupled receptor (GPCR) signaling.Transcriptional and posttranslational regulation of insulin-like growth factor binding protein-3 by Akt3.Suppression of feedback loops mediated by PI3K/mTOR induces multiple overactivation of compensatory pathways: an unintended consequence leading to drug resistance.Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation.Not just gRASping at flaws: finding vulnerabilities to develop novel therapies for treating KRAS mutant cancers Androgen deprivation-induced NCoA2 promotes metastatic and castration-resistant prostate cancer.P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer.Adhesion glycoprotein CD44 functions as an upstream regulator of a network connecting ERK, AKT and Hippo-YAP pathways in cancer progression p70 S6-kinase mediates the cooperation between Akt1 and Mek1 pathways in fibroblast-mediated extracellular matrix remodeling High basal Wnt signaling is further induced by PI3K/mTor inhibition but sensitive to cSRC inhibition in mammary carcinoma cell lines with HER2/3 overexpression.Oncogenic mutations of thyroid hormone receptor β.IRGM1 enhances B16 melanoma cell metastasis through PI3K-Rac1 mediated epithelial mesenchymal transition.Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression.Colon Cancer Tumorigenesis Initiated by the H1047R Mutant PI3K.Context-specific functional module based drug efficacy prediction.PIK3CA mutations can initiate pancreatic tumorigenesis and are targetable with PI3K inhibitors Identification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations Deficiency of myotubularin-related protein 14 influences body weight, metabolism, and inflammation in an age-dependent manner.Low-Dose Radiation Induces Cell Proliferation in Human Embryonic Lung Fibroblasts but not in Lung Cancer Cells: Importance of ERK1/2 and AKT Signaling Pathways Measurement of PIP3 levels reveals an unexpected role for p110β in early adaptive responses to p110α-specific inhibitors in luminal breast cancer.Akt Regulates Axon Wrapping and Myelin Sheath Thickness in the PNS Thyrostimulin-TSHR signaling promotes the proliferation of NIH:OVCAR-3 ovarian cancer cells via trans-regulation of the EGFR pathway.Melatonin enhances sensitivity to fluorouracil in oesophageal squamous cell carcinoma through inhibition of Erk and Akt pathway Characterization of a P-Rex1 gene signature in breast cancer cells Periostin induces intracellular cross-talk between kinases and hyaluronan in atrioventricular valvulogenesis.RAC1 GTP-ase signals Wnt-beta-catenin pathway mediated integrin-directed metastasis-associated tumor cell phenotypes in triple negative breast cancers.The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries

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PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1.

http://www.wikidata.org/entity/Q37421358

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 10 December 2013

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1.

@en

PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1.

@nl

type

label

PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1.

@en

PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1.

@nl

prefLabel

PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1.

@en

PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1.

@nl

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PNAS.1314124110

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Proceedings of the National Academy of Sciences of the United States of America

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PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1.

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Anthony C Faber

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Carlotta Costa

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Cyril H Benes

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Dejan Juric

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Hiromichi Ebi

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Hiroshi Kotani

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Jeffrey A Engelman

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Madhuri Nishtala

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Patricia Della Pelle

http://www.w3.org/2001/XMLSchema#string

Seiji Yano

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P2860

Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells

PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer

Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.

Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers.

Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo.

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

Systematic identification of genomic markers of drug sensitivity in cancer cells

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

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21124-21129

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scholarly article

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10.1073/PNAS.1314124110

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52

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110

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Mari Mino-Kenudson

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2013-12-10T00:00:00Z

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259271523

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24327733

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3876254

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