Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response.
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Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase LinkerNon-degradative Ubiquitination of Protein Kinases.Quantitative analysis of protein phosphorylations and interactions by multi-colour IP-FCM as an input for kinetic modelling of signalling networksRole of dynamics in the autoinhibition and activation of the exchange protein directly activated by cyclic AMP (EPAC)ERK positive feedback regulates a widespread network of tyrosine phosphorylation sites across canonical T cell signaling and actin cytoskeletal proteins in Jurkat T cells.Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding.The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.The SYK tyrosine kinase: a crucial player in diverse biological functions.Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases.CD25 and CD69 induction by α4β1 outside-in signalling requires TCR early signalling complex proteins.ZAP-70: an essential kinase in T-cell signalingNew insights into the T cell synapse from single molecule techniques.T cell receptor dwell times control the kinase activity of Zap70.Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness.Molecular mechanism of selective recruitment of Syk kinases by the membrane antigen-receptor complex.Src homology 2 domains enhance tyrosine phosphorylation in vivo by protecting binding sites in their target proteins from dephosphorylation.Selected signalling proteins recruited to the T-cell receptor-CD3 complex.
P2860
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P2860
Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response.
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2009 nî lūn-bûn
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name
Stability of an autoinhibitory ...... acts T cell receptor response.
@en
Stability of an autoinhibitory ...... acts T cell receptor response.
@nl
type
label
Stability of an autoinhibitory ...... acts T cell receptor response.
@en
Stability of an autoinhibitory ...... acts T cell receptor response.
@nl
prefLabel
Stability of an autoinhibitory ...... acts T cell receptor response.
@en
Stability of an autoinhibitory ...... acts T cell receptor response.
@nl
P2860
P50
P356
P1476
Stability of an autoinhibitory ...... acts T cell receptor response.
@en
P2093
John Kuriyan
Xiaoxian Cao
P2860
P304
20699-20704
P356
10.1073/PNAS.0911512106
P407
P577
2009-11-17T00:00:00Z