Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases.
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B cell activation involves nanoscale receptor reorganizations and inside-out signaling by SykB lymphocyte antigen receptor signaling: initiation, amplification, and regulationPhosphorylation site dynamics of early T-cell receptor signalingAutoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.No receptor stands alone: IgG B-cell receptor intrinsic and extrinsic mechanisms contribute to antibody memoryCLEC-2-dependent activation of mouse platelets is weakly inhibited by cAMP but not by cGMPEncoding immunological memory in the initiation of B-cell receptor signalingAn Interaction Library for the FcεRI Signaling NetworkSyk tyrosine kinase is critical for B cell antibody responses and memory B cell survival.The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.A Computational Study of the Effects of Syk Activity on B Cell Receptor Signaling DynamicsUtilization of a photoactivatable antigen system to examine B-cell probing termination and the B-cell receptor sorting mechanisms during B-cell activation.Dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis.An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor.Multidimensional single-cell analysis of BCR signaling reveals proximal activation defect as a hallmark of chronic lymphocytic leukemia B cells.Rule-based modeling: a computational approach for studying biomolecular site dynamics in cell signaling systems.B-lymphocyte tolerance and effector function in immunity and autoimmunity.Molecular requirements of the B-cell antigen receptor for sensing monovalent antigens.FcγRIIB-Independent Mechanisms Controlling Membrane Localization of the Inhibitory Phosphatase SHIP in Human B Cells.Peptide-based synthetic vaccines.Mechanisms of central tolerance for B cells.Differential Requirements for Src-Family Kinases in SYK or ZAP70-Mediated SLP-76 Phosphorylation in Lymphocytes.Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B Cells.Decoding the language of phosphorylation site dynamics.Positive Regulation of Lyn Kinase by CD148 Is Required for B Cell Receptor Signaling in B1 but Not B2 B Cells.TCR Signaling: Mechanisms of Initiation and Propagation.
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P2860
Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Monovalent and multivalent lig ...... on Syk and Src family kinases.
@en
Monovalent and multivalent lig ...... on Syk and Src family kinases.
@nl
type
label
Monovalent and multivalent lig ...... on Syk and Src family kinases.
@en
Monovalent and multivalent lig ...... on Syk and Src family kinases.
@nl
prefLabel
Monovalent and multivalent lig ...... on Syk and Src family kinases.
@en
Monovalent and multivalent lig ...... on Syk and Src family kinases.
@nl
P2093
P2860
P50
P1433
P1476
Monovalent and multivalent lig ...... on Syk and Src family kinases.
@en
P2093
Hidde Ploegh
Jayajit Das
John Kuriyan
Ramya Parameswaran
Sayak Mukherjee
P2860
P356
10.1126/SCISIGNAL.2003220
P577
2013-01-01T00:00:00Z