Type 1 diabetes development requires both CD4+ and CD8+ T cells and can be reversed by non-depleting antibodies targeting both T cell populations.
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Anti-Insulin Immune Responses Are Detectable in Dogs with Spontaneous DiabetesThe immunosuppressive role of adenosine A2A receptors in ischemia reperfusion injury and islet transplantation.Oral therapy for type 1 diabetes mellitus using a novel immunomodulator, FTY720 (fingolimod), in combination with sitagliptin, a dipeptidyl peptidase-4 inhibitor, examined in non-obese diabetic miceType-specific human papillomavirus detection in cervical smears in Romania.Inhibition of Phosphoinositide 3-Kinase p110delta Does Not Affect T Cell Driven Development of Type 1 Diabetes Despite Significant Effects on Cytokine Production.Long-term remission of diabetes in NOD mice is induced by nondepleting anti-CD4 and anti-CD8 antibodiesPathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease.Wnt signaling inhibits CTL memory programming.Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies.Anti-coreceptor therapy drives selective T cell egress by suppressing inflammation-dependent chemotactic cues.Soluble factors secreted by T cells promote β-cell proliferation.B cell depletion in autoimmune diabetes: insights from murine models.What causes type 1 diabetes? Lessons from animal models.Autoimmunity and inflammation: murine models and translational studies.Inflammation and type one diabetes.Cell-based interventions to halt autoimmunity in type 1 diabetes mellitus.Less is more: the detrimental consequences of immunosuppressive therapy in the treatment of type-1 diabetes.Lessons from the mouse: potential contribution of bystander lymphocyte activation by viruses to human type 1 diabetes.Rotavirus acceleration of murine type 1 diabetes is associated with a T helper 1-dependent specific serum antibody response and virus effects in regional lymph nodes.Theranostic magnetic resonance imaging of type 1 diabetes and pancreatic islet transplantation.Foxp3(+) regulatory T cells in mouse models of type 1 diabetesIn Vivo Depletion of T Lymphocytes.Deficiency of Nuclear Factor-κB c-Rel Accelerates the Development of Autoimmune Diabetes in NOD Mice.Breakthrough in diabetes therapy ... Just around the corner?Antibody Binding to CD4 Induces Rac GTPase Activation and Alters T Cell Migration.Antigen peptide transporter 1 is involved in the development of fructose-induced hepatic steatosis in mice.Mitochondrial Reactive Oxygen Species and Type 1 Diabetes.CD8+ T Cells Effect Glomerular Injury in Experimental Anti-Myeloperoxidase GN.Paquinimod prevents development of diabetes in the non-obese diabetic (NOD) mouse.Therapies to Suppress β Cell Autoimmunity in Type 1 Diabetes
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Type 1 diabetes development requires both CD4+ and CD8+ T cells and can be reversed by non-depleting antibodies targeting both T cell populations.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 10 August 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Type 1 diabetes development re ...... eting both T cell populations.
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Type 1 diabetes development re ...... eting both T cell populations.
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Type 1 diabetes development re ...... eting both T cell populations.
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Type 1 diabetes development re ...... eting both T cell populations.
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Type 1 diabetes development re ...... eting both T cell populations.
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Type 1 diabetes development re ...... eting both T cell populations.
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P2093
P2860
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Type 1 diabetes development re ...... geting both T cell populations
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Anne Cooke
Chris Bland
Hugo De La Peña
Jenny M Phillips
Nicole M Parish
Yvonne Sawyer
P2860
P304
P356
10.1900/RDS.2009.6.97
P50
P577
2009-08-10T00:00:00Z