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Effect of Iboga alkaloids on µ-opioid receptor-coupled G protein activationGain-of-function ADCY5 mutations in familial dyskinesia with facial myokymiaCrystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonateThe cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory DiseasesGlobal and local missions of cAMP signaling in neural plasticity, learning, and memoryRegulation of nephron water and electrolyte transport by adenylyl cyclasesSimilarly potent inhibition of adenylyl cyclase by P-site inhibitors in hearts from wild type and AC5 knockout miceType VI adenylyl cyclase negatively regulates GluN2B-mediated LTD and spatial reversal learning.Crystal Structure and Regulation Mechanisms of the CyaB Adenylyl Cyclase from the Human Pathogen Pseudomonas aeruginosaType 3 adenylyl cyclase: a key enzyme mediating the cAMP signaling in neuronal ciliaThe small molecule triclabendazole decreases the intracellular level of cyclic AMP and increases resistance to stress in Saccharomyces cerevisiaeSmall molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytescAMP ameliorates inflammation by modulation of macrophage receptor for advanced glycation end-productsImpaired water reabsorption in mice deficient in the type VI adenylyl cyclase (AC6)Network Architecture Predisposes an Enzyme to Either Pharmacologic or Genetic Targeting.Time-resolved in silico modeling of fine-tuned cAMP signaling in platelets: feedback loops, titrated phosphorylations and pharmacological modulation.Advances in targeting cyclic nucleotide phosphodiesterasesThe N terminus of phosphodiesterase TbrPDEB1 of Trypanosoma brucei contains the signal for integration into the flagellar skeleton.Regulation of GPCR signaling in hypertension.Identification of a haem domain in human soluble adenylate cyclase.A role for Piezo2 in EPAC1-dependent mechanical allodynia.The absence of mrp4 has no effect on the recruitment of neutrophils and eosinophils into the lung after LPS, cigarette smoke or allergen challenge.Isoform selectivity of adenylyl cyclase inhibitors: characterization of known and novel compoundsDevelopment of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor.Inhibitors of membranous adenylyl cyclases.High-Intensity Swimming Exercise Decreases Glutamate-Induced Nociception by Activation of G-Protein-Coupled Receptors Inhibiting Phosphorylated Protein Kinase A.Comparative electrostatic analysis of adenylyl cyclase for isoform dependent regulation properties.Post-translational modifications of voltage-gated sodium channels in chronic pain syndromesMYCBP2 Is a Guanosine Exchange Factor for Ran Protein and Determines Its Localization in Neurons of Dorsal Root Ganglia.Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties.Termination and activation of store-operated cyclic AMP production.The pleiotropic role of exchange protein directly activated by cAMP 1 (EPAC1) in cancer: implications for therapeutic intervention.Calmodulin-sensitive adenylyl cyclases mediate AVP-dependent cAMP production and Cl- secretion by human autosomal dominant polycystic kidney cells.A new site and mechanism of action for the widely used adenylate cyclase inhibitor SQ22,536Adenylyl cyclase VI mediates vasopressin-stimulated ENaC activity.The complex of G protein regulator RGS9-2 and Gβ(5) controls sensitization and signaling kinetics of type 5 adenylyl cyclase in the striatumRegions on adenylyl cyclase VII required for selective regulation by the G13 pathwayBithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator SiteAn 18 gene expression-based score classifier predicts the clinical outcome in stage 4 neuroblastoma.miRNA expression in pediatric failing human heart.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Capturing adenylyl cyclases as potential drug targets.
@en
Capturing adenylyl cyclases as potential drug targets.
@nl
type
label
Capturing adenylyl cyclases as potential drug targets.
@en
Capturing adenylyl cyclases as potential drug targets.
@nl
prefLabel
Capturing adenylyl cyclases as potential drug targets.
@en
Capturing adenylyl cyclases as potential drug targets.
@nl
P2093
P356
P1476
Capturing adenylyl cyclases as potential drug targets.
@en
P2093
Gerd Geisslinger
Klaus Scholich
Sandra Pierre
Thomas Eschenhagen
P2888
P304
P356
10.1038/NRD2827
P577
2009-04-01T00:00:00Z