A role for Piezo2 in EPAC1-dependent mechanical allodynia. - Wikidata - awgldk - TriplyDB

A role for Piezo2 in EPAC1-dependent mechanical allodynia.

A role for Piezo2 in EPAC1-dependent mechanical allodynia.

http://www.wikidata.org/entity/Q34338475

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Mechanical allodynia Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors.Mammalian touch catches up Nerve growth factor mediates a switch in intracellular signaling for PGE2-induced sensitization of sensory neurons from protein kinase A to Epac Exchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeutics Exuberant sprouting of sensory and sympathetic nerve fibers in nonhealed bone fractures and the generation and maintenance of chronic skeletal pain.Mechanosensory hair cells express two molecularly distinct mechanotransduction channels.[EXPRESS] Epac and Nociceptor Sensitization.TRPA1: a transducer and amplifier of pain and inflammation.Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.Ionic mechanisms of spinal neuronal cold hypersensitivity in ciguatera.Piezo proteins: regulators of mechanosensation and other cellular processes Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.Piezo2 is the major transducer of mechanical forces for touch sensation in mice.Amplified Mechanically Gated Currents in Distinct Subsets of Myelinated Sensory Neurons following In Vivo Inflammation of Skin and Muscle.Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides.Upregulation of Ih expressed in IB4-negative Aδ nociceptive DRG neurons contributes to mechanical hypersensitivity associated with cervical radiculopathic pain.The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing.Epac activation sensitizes rat sensory neurons through activation of Ras.Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1.Regulation of Piezo2 Mechanotransduction by Static Plasma Membrane Tension in Primary Afferent Neurons IL4-10 Fusion Protein Is a Novel Drug to Treat Persistent Inflammatory Pain.α2δ-1 gene deletion affects somatosensory neuron function and delays mechanical hypersensitivity in response to peripheral nerve damage.Epac1 interacts with importin β1 and controls neurite outgrowth independently of cAMP and Rap1.GTP-dependent run-up of Piezo2-type mechanically activated currents in rat dorsal root ganglion neurons.Piezo2 protein: A novel regulator of tumor angiogenesis and hyperpermeability Piezo channels: from structure to function.Transduction and encoding sensory information by skin mechanoreceptors.Pain without nociceptors? Nav1.7-independent pain mechanisms.Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension.Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels.Neural circuits for pain: Recent advances and current views.Merkel cells transduce and encode tactile stimuli to drive Aβ-afferent impulses.Piezo2 in Cutaneous and Proprioceptive Mechanotransduction in Vertebrates.Effect of Epac1 on pERK and VEGF Activation in Postoperative Persistent Pain in Rats.Cutaneous pigmentation modulates skin sensitivity via tyrosinase-dependent dopaminergic signalling Piezo2 expression in corneal afferent neurons.Cell-Type-Specific Splicing of Piezo2 Regulates Mechanotransduction.Contribution of Piezo2 to endothelium-dependent pain.PIEZO2 as the anomalous mechanotransducer channel in auditory hair cells.

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A role for Piezo2 in EPAC1-dependent mechanical allodynia.

http://www.wikidata.org/entity/Q34338475

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2013 nî lūn-bûn

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2013 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2013年の論文

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2013年論文

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name

A role for Piezo2 in EPAC1-dependent mechanical allodynia.

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A role for Piezo2 in EPAC1-dependent mechanical allodynia.

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A role for Piezo2 in EPAC1-dependent mechanical allodynia.

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type

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A role for Piezo2 in EPAC1-dependent mechanical allodynia.

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A role for Piezo2 in EPAC1-dependent mechanical allodynia.

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A role for Piezo2 in EPAC1-dependent mechanical allodynia.

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A role for Piezo2 in EPAC1-dependent mechanical allodynia.

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A role for Piezo2 in EPAC1-dependent mechanical allodynia.

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A role for Piezo2 in EPAC1-dependent mechanical allodynia.

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Nature Communications

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A role for Piezo2 in EPAC1-dependent mechanical allodynia

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A H Dickenson

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E Lee

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F J Zwartkuis

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G S Hong

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J J Cox

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J M Torres

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J N Wood

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L Bee

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M Gringhuis

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M S Minett

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P2860

Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices

The role of Drosophila Piezo in mechanical nociception

Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons

Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels

Cell physiology of cAMP sensor Epac.

An SCN9A channelopathy causes congenital inability to experience pain

Quantitative assessment of tactile allodynia in the rat paw

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells.

The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways.

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10.1038/NCOMMS2673

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Niels Eijkelkamp

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