A xanthine-derivative K(+)-channel opener protects against serotonin-induced cardiomyocyte hypertrophy via the modulation of protein kinases

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The Xanthine Derivative KMUP-1 Attenuates Serotonin-Induced Vasoconstriction and K⁺-Channel Inhibitory Activity via the PKC Pathway in Pulmonary Arteries

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Q35632713-DFFDBE09-FF9F-429E-931B-4CCF14B4A345

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A xanthine-derivative K(+)-channel opener protects against serotonin-induced cardiomyocyte hypertrophy via the modulation of protein kinases

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 17 December 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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A xanthine-derivative K

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A xanthine-derivative K(+)-cha ...... modulation of protein kinases

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A xanthine-derivative K

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A xanthine-derivative K(+)-cha ...... modulation of protein kinases

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A xanthine-derivative K

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A xanthine-derivative K(+)-cha ...... modulation of protein kinases

@en

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A xanthine-derivative K(+)-cha ...... modulation of protein kinases

@en

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Bin-Nan Wu

http://www.w3.org/2001/XMLSchema#string

Chih-Sheng Chu

http://www.w3.org/2001/XMLSchema#string

Hsuan-Fu Kuo

http://www.w3.org/2001/XMLSchema#string

Ing-Jun Chen

http://www.w3.org/2001/XMLSchema#string

Jiunn-Ren Wu

http://www.w3.org/2001/XMLSchema#string

Jung-Chou Wu

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Kun-Tai Lee

http://www.w3.org/2001/XMLSchema#string

Yan-Jie Lai

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Involvement of the serotonin 5-HT2B receptor in cardiac hypertrophy linked to sympathetic stimulation: control of interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha cytokine production by ventricular fibroblasts

A xanthine-based KMUP-1 with cyclic GMP enhancing and K(+) channels opening activities in rat aortic smooth muscle

Dual serotonergic regulation of ventricular contractile force through 5-HT2A and 5-HT4 receptors induced in the acute failing heart

KMUP-1 attenuates isoprenaline-induced cardiac hypertrophy in rats through NO/cGMP/PKG and ERK1/2/calcineurin A pathways

Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes.

The xanthine derivative KMUP-1 inhibits models of pulmonary artery hypertension via increased NO and cGMP-dependent inhibition of RhoA/Rho kinase

Long-term serotonin administration induces heart valve disease in rats.

Protein kinases modulate store-operated channels in pulmonary artery smooth muscle cells.

KMUP-1 relaxes rabbit corpus cavernosum smooth muscle in vitro and in vivo: involvement of cyclic GMP and K(+) channels

Electrophysiological effects of 5-hydroxytryptamine on isolated human atrial myocytes, and the influence of chronic beta-adrenoceptor blockade.

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64-72

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scholarly article

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10.7150/IJBS.7894

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English

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http://www.w3.org/2001/XMLSchema#string

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2013-12-17T00:00:00Z

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259588853

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P698

24391452

http://www.w3.org/2001/XMLSchema#string

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serotonin

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3879592

http://www.w3.org/2001/XMLSchema#string

A xanthine-derivative K(+)-channel opener protects against serotonin-induced cardiomyocyte hypertrophy via the modulation of protein kinases

about

P2860

P2860

A xanthine-derivative K(+)-channel opener protects against serotonin-induced cardiomyocyte hypertrophy via the modulation of protein kinases

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P1433

P1476

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P356

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P1476

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