Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB.
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Pharmacological Modulators of Endoplasmic Reticulum Stress in Metabolic DiseasesLost in translation: endoplasmic reticulum stress and the decline of β-cell health in diabetes mellitusGuards and culprits in the endoplasmic reticulum: glucolipotoxicity and β-cell failure in type II diabetesGLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein BimMcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosisGIP and GLP-1, the two incretin hormones: Similarities and differencesGlucose-dependent insulinotropic polypeptide signaling in pancreatic β-cells and adipocytesLipotoxicity and decreased islet graft survivalThe importance of the cellular stress response in the pathogenesis and treatment of type 2 diabetes.Blood fluke exploitation of non-cognate CD4+ T cell help to facilitate parasite development.JunB protects β-cells from lipotoxicity via the XBP1-AKT pathway.GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing the unfolded protein response and promoting macroautophagy.Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance.PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim.Wolcott-Rallison syndromePalmitic acid acutely inhibits acetylcholine- but not GLP-1-stimulated insulin secretion in mouse pancreatic islets.The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines.Exendin-4 Protects MIN6 Cells from t-BHP-Induced Apoptosis via IRE1-JNK-Caspase-3 SignalingFrequency and spectrum of Wolcott-Rallison syndrome in Saudi Arabia: a systematic review.The transcription factor Myt3 acts as a pro-survival factor in β-cellsChanges in BiP availability reveal hypersensitivity to acute endoplasmic reticulum stress in cells expressing mutant huntingtin.PKA phosphorylation couples hepatic inositol-requiring enzyme 1alpha to glucagon signaling in glucose metabolism.Crosstalk between intestinal microbiota, adipose tissue and skeletal muscle as an early event in systemic low-grade inflammation and the development of obesity and diabetes.Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets.Lipotoxic Stress Induces Pancreatic β-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System.A noncytolytic antibody-like extendin-4-IgG4 fusion protein as a long-acting potential anti-diabetic agent.Regulation of Pancreatic β Cell Mass by Cross-Interaction between CCAAT Enhancer Binding Protein β Induced by Endoplasmic Reticulum Stress and AMP-Activated Protein Kinase Activity.Lipolysis response to endoplasmic reticulum stress in adipose cells.Exendin-4 protects bone marrow-derived mesenchymal stem cells against oxygen/glucose and serum deprivation-induced apoptosis through the activation of the cAMP/PKA signaling pathway and the attenuation of ER stressEnhanced GLP-1- and sulfonylurea-induced insulin secretion in islets lacking leptin signaling.Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis.Choosing between GLP-1 Receptor Agonists and DPP-4 Inhibitors: A Pharmacological Perspective.Glucagon-like peptide-1 protects cardiomyocytes from advanced oxidation protein product-induced apoptosis via the PI3K/Akt/Bad signaling pathway.ER Stress and β-Cell Pathogenesis of Type 1 and Type 2 Diabetes and Islet Transplantation.Update on the protective molecular pathways improving pancreatic beta-cell dysfunctionCentral role and mechanisms of β-cell dysfunction and death in friedreich ataxia-associated diabetes.Dipeptidyl Peptidase-4 Inhibitor Use Is Not Associated With Acute Pancreatitis in High-Risk Type 2 Diabetic Patients: A Nationwide Cohort StudyMorphine Protects Spinal Cord Astrocytes from Glutamate-Induced Apoptosis via Reducing Endoplasmic Reticulum Stress.Resistance to type 2 diabetes mellitus: a matter of hormesis?The potential role of glutamate in the current diabetes epidemic.
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P2860
Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 31 August 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Glucagon-like peptide-1 agonis ...... upregulation of BiP and JunB.
@en
Glucagon-like peptide-1 agonis ...... upregulation of BiP and JunB.
@nl
type
label
Glucagon-like peptide-1 agonis ...... upregulation of BiP and JunB.
@en
Glucagon-like peptide-1 agonis ...... upregulation of BiP and JunB.
@nl
prefLabel
Glucagon-like peptide-1 agonis ...... upregulation of BiP and JunB.
@en
Glucagon-like peptide-1 agonis ...... upregulation of BiP and JunB.
@nl
P2093
P2860
P50
P356
P1433
P1476
Glucagon-like peptide-1 agonis ...... upregulation of BiP and JunB.
@en
P2093
Daniel A Cunha
Décio L Eizirik
Laurence Ladrière
Mariana Igoillo-Esteve
Roberto Lupi
P2860
P304
P356
10.2337/DB09-0685
P407
P577
2009-08-31T00:00:00Z