Localization, purification, and functional reconstitution of the P4-ATPase Atp8a2, a phosphatidylserine flippase in photoreceptor disc membranes.
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Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPasesDifferential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutantsATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent mannerP4-ATPases as Phospholipid Flippases-Structure, Function, and EnigmasMammalian P4-ATPases and ABC transporters and their role in phospholipid transportComplex control of GABA(A) receptor subunit mRNA expression: variation, covariation, and genetic regulationLoss of the Arabidopsis thaliana P₄-ATPase ALA3 reduces adaptability to temperature stresses and impairs vegetative, pollen, and ovule developmentMutations in a P-type ATPase gene cause axonal degenerationThe lipid translocase, ABCA4: seeing is believing.The Essential Neo1 Protein from Budding Yeast Plays a Role in Establishing Aminophospholipid Asymmetry of the Plasma Membrane.The yeast plasma membrane ATP binding cassette (ABC) transporter Aus1: purification, characterization, and the effect of lipids on its activity.Human Type IV P-type ATPases That Work as Plasma Membrane Phospholipid Flippases and Their Regulation by Caspase and CalciumP4-ATPases: lipid flippases in cell membranesLipid somersaults: Uncovering the mechanisms of protein-mediated lipid flippingP4 ATPases: flippases in health and diseasePhospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival.Proteomic identification of unique photoreceptor disc components reveals the presence of PRCD, a protein linked to retinal degenerationP4-ATPase ATP8A2 acts in synergy with CDC50A to enhance neurite outgrowthRole for phospholipid flippase complex of ATP8A1 and CDC50A proteins in cell migrationAtp8a1 deficiency is associated with phosphatidylserine externalization in hippocampus and delayed hippocampus-dependent learningUner Tan syndrome caused by a homozygous TUBB2B mutation affecting microtubule stabilityMapping functional interactions in a heterodimeric phospholipid pumpDefective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration.Loss of the Arabidopsis thaliana P4-ATPases ALA6 and ALA7 impairs pollen fitness and alters the pollen tube plasma membraneIntracellular targeting signals and lipid specificity determinants of the ALA/ALIS P4-ATPase complex reside in the catalytic ALA alpha-subunit.Disruption of the lipid-transporting LdMT-LdRos3 complex in Leishmania donovani affects membrane lipid asymmetry but not host cell invasionEvaluation of fluorescent phosphatidylserine substrates for the aminophospholipid flippase in mammalian cells.Functions of phospholipid flippases.Defective lipid transport and biosynthesis in recessive and dominant Stargardt macular degenerationEffect of light on global gene expression in the neuroglobin-deficient mouse retina.Overexpression of rod photoreceptor glutamic acid rich protein 2 (GARP2) increases gain and slows recovery in mouse retina.Disruption of the ATP8A2 gene in a patient with a t(10;13) de novo balanced translocation and a severe neurological phenotype.CDC50 proteins are critical components of the human class-1 P4-ATPase transport machinery.Role of flippases, scramblases and transfer proteins in phosphatidylserine subcellular distributionPhosphatidylserine in the brain: metabolism and function.Opsin is a phospholipid flippaseRole of membrane integrity on G protein-coupled receptors: Rhodopsin stability and function.Transport through recycling endosomes requires EHD1 recruitment by a phosphatidylserine translocase.Critical role of a transmembrane lysine in aminophospholipid transport by mammalian photoreceptor P4-ATPase ATP8A2Identification of residues defining phospholipid flippase substrate specificity of type IV P-type ATPases.
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Localization, purification, and functional reconstitution of the P4-ATPase Atp8a2, a phosphatidylserine flippase in photoreceptor disc membranes.
description
article científic
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article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 24 September 2009
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Localization, purification, an ...... photoreceptor disc membranes.
@en
Localization, purification, an ...... photoreceptor disc membranes.
@nl
type
label
Localization, purification, an ...... photoreceptor disc membranes.
@en
Localization, purification, an ...... photoreceptor disc membranes.
@nl
prefLabel
Localization, purification, an ...... photoreceptor disc membranes.
@en
Localization, purification, an ...... photoreceptor disc membranes.
@nl
P2093
P2860
P356
P1476
Localization, purification, an ...... photoreceptor disc membranes.
@en
P2093
Jonathan A Coleman
Michael C M Kwok
Robert S Molday
P2860
P304
32670-32679
P356
10.1074/JBC.M109.047415
P407
P577
2009-09-24T00:00:00Z