Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity. - Wikidata - awgldk - TriplyDB

Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity.

Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity.

http://www.wikidata.org/entity/Q37432488

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Inhibition of xanthine oxidase reduces oxidative stress and improves skeletal muscle function in response to electrically stimulated isometric contractions in aged mice Is the oxidative stress theory of aging dead?Beyond Diabetes: Does Obesity-Induced Oxidative Stress Drive the Aging Process?ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases Biochemical Genetic Pathways that Modulate Aging in Multiple Species Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel Does reduced IGF-1R signaling in Igf1r+/- mice alter aging?NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?The hallmarks of aging Nuclear Factor-Erythroid-2-Related Factor 2 in Aging and Lung Fibrosis Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling Long-term supplementation with resveratrol alleviates oxidative stress but does not attenuate sarcopenia in aged mice Mitochondria and oxidative stress in heart aging Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications Suppression of oxidative stress by resveratrol after isometric contractions in gastrocnemius muscles of aged mice Elevated mitochondrial oxidative stress impairs metabolic adaptations to exercise in skeletal muscle Hyperoxygenation attenuated a murine model of atopic dermatitis through raising skin level of ROS Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production?Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response ROS function in redox signaling and oxidative stress Signal transduction by reactive oxygen species Mitochondrial peptidase IMMP2L mutation causes early onset of age-associated disorders and impairs adult stem cell self-renewal Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging?European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).The free-radical damage theory: Accumulating evidence against a simple link of oxidative stress to ageing and lifespan.Taking a "good" look at free radicals in the aging process.Antioxidant vitamins and mineral supplementation, life span expansion and cancer incidence: a critical commentary.A mild impairment of mitochondrial electron transport has sex-specific effects on lifespan and aging in mice.Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity.A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations Mouse Models of Oxidative Stress Indicate a Role for Modulating Healthy Aging.Aging and energetics' 'Top 40' future research opportunities 2010-2013.Can rodent longevity studies be both short and powerful?Computational modelling of the regulation of Insulin signalling by oxidative stress.Mitochondrial DNA mutations in disease and aging Quercetin and cancer chemoprevention Reactive oxygen species prevent imiquimod-induced psoriatic dermatitis through enhancing regulatory T cell function Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta.Attenuation of experimental colitis in glutathione peroxidase 1 and catalase double knockout mice through enhancing regulatory T cell function Life-extending dietary restriction and ovariectomy result in similar feeding rates but different physiologic responses in grasshoppers

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Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity.

http://www.wikidata.org/entity/Q37432488

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article científic

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bilimsel makale

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scientific article published on 23 September 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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Mice deficient in both Mn supe ...... but no reduction in longevity.

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Mice deficient in both Mn supe ...... but no reduction in longevity.

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Mice deficient in both Mn supe ...... but no reduction in longevity.

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Mice deficient in both Mn supe ...... but no reduction in longevity.

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Mice deficient in both Mn supe ...... but no reduction in longevity.

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Mice deficient in both Mn supe ...... but no reduction in longevity.

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The Journals of Gerontology

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Mice deficient in both Mn supe ...... but no reduction in longevity.

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Alex Bokov

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Arlan Richardson

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Asish Chaudhuri

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Charles Epstein

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John W Baynes

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Suzanne R Thorpe

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Wenbo Qi

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Yan Li

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Yiqiang Zhang

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Yuji Ikeno

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P2860

Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans

The in vivo gene expression signature of oxidative stress

Biological approaches to mechanistically understand the healthy life span extension achieved by calorie restriction and modulation of hormones

Aging: a theory based on free radical and radiation chemistry

A reliable assessment of 8-oxo-2-deoxyguanosine levels in nuclear and mitochondrial DNA using the sodium iodide method to isolate DNA

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

Trends in oxidative aging theories

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

Peroxiredoxin 5 confers protection against oxidative stress and apoptosis and also promotes longevity in Drosophila

Knockout of cellular glutathione peroxidase gene renders mice susceptible to diquat-induced oxidative stress

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1212-1220

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scholarly article

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10.1093/GERONA/GLP132

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12

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64

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Holly Van Remmen

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2009-09-23T00:00:00Z

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26833318

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19776219

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2781787

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