Mutations in mitochondrial DNA polymerase-gamma promote breast tumorigenesis
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Mitochondrial DNA alterations and mitochondrial dysfunction in the progression of hepatocellular carcinomaRole of mitochondrial dysfunction in cancer progressionMitochondrial genome regulates mitotic fidelity by maintaining centrosomal homeostasis.Impaired OXPHOS complex III in breast cancerCellular model of Warburg effect identifies tumor promoting function of UCP2 in breast cancer and its suppression by genipinCAG repeat variants in the POLG1 gene encoding mtDNA polymerase-gamma and risk of breast cancer in African-American womenActivation of Akt is essential for the propagation of mitochondrial respiratory stress signaling and activation of the transcriptional coactivator heterogeneous ribonucleoprotein A2Overexpression of DNA polymerase zeta reduces the mitochondrial mutability caused by pathological mutations in DNA polymerase gamma in yeast.Polymorphisms in DNA polymerase γ affect the mtDNA stability and the NRTI-induced mitochondrial toxicity in Saccharomyces cerevisiae.The energy blocker inside the power house: Mitochondria targeted delivery of 3-bromopyruvate.The awakening of an advanced malignant cancer: an insult to the mitochondrial genomeHuman REV3 DNA Polymerase Zeta Localizes to Mitochondria and Protects the Mitochondrial Genome.Mitochondrial DNA Polymerase POLG1 Disease Mutations and Germline Variants Promote Tumorigenic Properties.Correlated tissue expression of genes of cytoplasmic and mitochondrial nucleotide metabolisms in normal tissues is disrupted in transformed tissuesGenetic insights into OXPHOS defect and its role in cancerSilencing of IkBβ mRNA causes disruption of mitochondrial retrograde signaling and suppression of tumor growth in vivo.Mutations in human DNA polymerase γ confer unique mechanisms of catalytic deficiency that mirror the disease severity in mitochondrial disorder patients.Impaired mitochondrial metabolism and mammary carcinogenesisCell-free circulating mitochondrial DNA content and risk of hepatocellular carcinoma in patients with chronic HBV infection.Role of Mitochondrial DNA Copy Number Alteration in Human Renal Cell Carcinoma.Pre-diagnostic leukocyte mitochondrial DNA copy number and risk of lung cancerMitochondrial DNA mutations and breast tumorigenesis.Somatic alterations in mitochondrial DNA and mitochondrial dysfunction in gastric cancer progressionTrinucleotide repeat expansions in human breast cancer-susceptibility genes: relevant targets for aspirin chemoprevention?The control of mitochondrial DNA replication during development and tumorigenesis.Mitochondria and Mitochondrial ROS in Cancer: Novel Targets for Anticancer Therapy.Radiogenomics: A systems biology approach to understanding genetic risk factors for radiotherapy toxicity?Mitochondrial determinants of cancer health disparities.Mitochondrial dysfunction in cancer: Potential roles of ATF5 and the mitochondrial UPR.Defining the momiome: Promiscuous information transfer by mobile mitochondria and the mitochondrial genome.Mitochondrial DNA as an initiator of tumorigenesis.High TIMM17A expression is associated with adverse pathological and clinical outcomes in human breast cancer.Somatic mitochondrial DNA mutations in Chinese patients with osteosarcoma.Epigenetic modification of miR-663 controls mitochondria-to-nucleus retrograde signaling and tumor progression.Somatic mutations of the mitochondrial genome in human breast cancers.Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases.Mitochondrial Dysfunction: A Novel Potential Driver of Epithelial-to-Mesenchymal Transition in Cancer.Difference in mitochondrial DNA copy number in peripheral blood cells between probands with autism spectrum disorders and their unaffected siblings.Mismatch Repair Proteins Initiate Epigenetic Alterations during Inflammation-Driven Tumorigenesis.Germline variants of base excision repair genes and breast cancer: A polymorphism in DNA polymerase gamma modifies gene expression and breast cancer risk.
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Mutations in mitochondrial DNA polymerase-gamma promote breast tumorigenesis
description
article científic
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article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 24 July 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Mutations in mitochondrial DNA polymerase-gamma promote breast tumorigenesis
@en
Mutations in mitochondrial DNA polymerase-gamma promote breast tumorigenesis.
@nl
type
label
Mutations in mitochondrial DNA polymerase-gamma promote breast tumorigenesis
@en
Mutations in mitochondrial DNA polymerase-gamma promote breast tumorigenesis.
@nl
prefLabel
Mutations in mitochondrial DNA polymerase-gamma promote breast tumorigenesis
@en
Mutations in mitochondrial DNA polymerase-gamma promote breast tumorigenesis.
@nl
P2093
P2860
P356
P1476
Mutations in mitochondrial DNA polymerase-gamma promote breast tumorigenesis
@en
P2093
Keshav K Singh
Kjerstin M Owens
Manika Sapru Koul
Marija Vujcic
Vanniarajan Ayyasamy
P2860
P2888
P304
P356
10.1038/JHG.2009.71
P577
2009-07-24T00:00:00Z