Triazole-dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration.
about
Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectivesEpigenetic regulation of DNA repair machinery in Helicobacter pylori-induced gastric carcinogenesisKDM1 class flavin-dependent protein lysine demethylasesEpigenetics: an emerging player in gastric cancerPro-Apoptotic Effects of JDA-202, a Novel Natural Diterpenoid, on Esophageal Cancer Through Targeting Peroxiredoxin I.Identification of Novel Selective Lysine-Specific Demethylase 1 (LSD1) Inhibitors Using a Pharmacophore-Based Virtual Screening Combined with Docking.Combinatorial Synthesis of Structurally Diverse Triazole-Bridged Flavonoid Dimers and Trimers.Lysine-specific demethylase 1 mediates epidermal growth factor signaling to promote cell migration in ovarian cancer cells.Structure activity relationship and modeling studies of inhibitors of lysine specific demethylase 1Downregulation of LSD1 suppresses the proliferation, tumorigenicity and invasion of papillary thyroid carcinoma K1 cells.3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1.Epigenetic molecular recognition: a biomolecular modeling perspective.Reversible inhibitors of LSD1 as therapeutic agents in acute myeloid leukemia: clinical significance and progress to date.Advances toward LSD1 inhibitors for cancer therapy.Medicinal chemistry insights in the discovery of novel LSD1 inhibitors.Multicomponent synthesis of some new (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-dithiocarbamates and their in vitro anti-proliferative activity against CaSki, MDA-MB-231 and SK-Lu-1 tumour cells as apoptosis inducing agents without necrosis.Design and synthesis of formononetin-dithiocarbamate hybrids that inhibit growth and migration of PC-3 cells via MAPK/Wnt signaling pathways.Inhibitors of Protein Methyltransferases and Demethylases.Design, Synthesis and Structure-Activity Relationships of Novel Chalcone-1,2,3-triazole-azole Derivates as Antiproliferative Agents.Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia.TCPs: privileged scaffolds for identifying potent LSD1 inhibitors for cancer therapy.Histone Lysine Demethylase Inhibitors.Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases.Multiple binding modes of ibuprofen in human serum albumin identified by absolute binding free energy calculations.How to stomach an epigenetic insult: the gastric cancer epigenome.In situ generation of N-unsubstituted imines from alkyl azides and their applications for imine transfer via copper catalysis.Structure-Activity Relationship Studies of β-Lactam-azide Analogues as Orally Active Antitumor Agents Targeting the Tubulin Colchicine Site.3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors.Discovery of 5,6-diaryl-1,2,4-triazines hybrids as potential apoptosis inducers.Molecular diversity of phenothiazines: design and synthesis of phenothiazine-dithiocarbamate hybrids as potential cell cycle blockers.Cyclic by peptide inhibitors of lysine-specific demethylase 1 with improved potency identified by alanine scanning mutagenesis.Discovery of [1,2,3]Triazolo[4,5-d]pyrimidine Derivatives as Novel LSD1 Inhibitors.Inhibition of lysine-specific demethylase 1 prevents proliferation and mediates cisplatin sensitivity in ovarian cancer cells.
P2860
Q26744441-1E6C6B1B-AD19-4780-AB50-6197F987BC33Q26796349-F66E78AF-2D6D-4B7E-A410-F0274FBFB7F8Q28084876-23AB46AE-EE93-41F0-9E04-530F6726BFA8Q33718259-9BFCC8F3-1A36-4054-8103-61003591D458Q33904801-E1D40B6E-54CA-4CE1-8E7D-532F00EEFEC9Q35367028-A3F773E5-86DE-463C-895C-AD3FF73BAA0FQ36138308-69DB6A86-EAB5-4305-A55C-3E1433965729Q36188499-73ECF8B5-64B2-4972-AC10-30B0E28B1321Q36269647-A936461A-B8F1-44BC-8FF5-5992717B4EFDQ36740912-32FD8B85-693D-459B-BB02-FBAC65966B55Q36930863-E6E8C725-5765-4637-8D52-F0F416719F48Q38195005-AB8B5192-1BF0-4375-86C8-F3CBF4886571Q38270780-BB316B45-302A-4E24-A7BD-F9C7BA379618Q38655327-5FFEB6AD-7AB1-437A-909A-204321FB09D1Q38662691-2F93EBC9-809F-4345-9615-F71AE11BC5CAQ38693416-E1AA95A6-E503-4DD1-9FC8-CE418E5BD740Q38723543-38AABF4C-DD1F-4764-BD5C-3F4FD1612696Q38740496-16C36BD1-AA1D-4BA7-9589-AA0E27788DAFQ38769198-7F1C72C5-12C4-4CC4-8352-F81749073AA1Q38786793-DAE3893E-19D1-484E-9407-B957158D372EQ38814417-1FE3968A-82E7-4308-8D37-40A8FACDD9E1Q39066287-487CAACA-8EF4-4289-BA3D-ABCAFC825704Q39171023-354D3A60-48B4-4872-915C-BB9E667EEB45Q39181234-D2E65765-9E3C-4BEA-A74A-B598E3DF446DQ39312802-7CFEB5EC-0432-43EE-8E66-132885F4191CQ40093117-FA938D1E-960F-4D0C-BE7A-BC49FB8F9FCBQ42371853-2AED4FD2-B9D6-473C-8335-37E556A1C1CFQ43094404-659780F3-F011-4EF0-AC85-16492F5C0A69Q43969190-FEC4AD99-EE16-4CAB-886B-C1B2D741C883Q46203621-F9FFCE15-C03F-4382-82AA-BD377A3F0372Q49833716-293FAA8F-D5FD-4D2D-9DC7-95822EB79D2CQ55041534-E2BE77E8-0AE1-443E-99FE-B86F1842A38DQ55260318-ECF70C53-B401-4965-A5D8-9AF1B3218B24
P2860
Triazole-dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
@zh
2013年學術文章
@zh-hant
name
Triazole-dithiocarbamate based ...... owth, invasion, and migration.
@en
Triazole-dithiocarbamate based ...... owth, invasion, and migration.
@nl
type
label
Triazole-dithiocarbamate based ...... owth, invasion, and migration.
@en
Triazole-dithiocarbamate based ...... owth, invasion, and migration.
@nl
prefLabel
Triazole-dithiocarbamate based ...... owth, invasion, and migration.
@en
Triazole-dithiocarbamate based ...... owth, invasion, and migration.
@nl
P2093
P2860
P356
P1476
Triazole-dithiocarbamate based ...... rowth, invasion, and migration
@en
P2093
Hong-Min Liu
Jin-Feng Li
Jin-Lian Ma
Jun-Wei Wang
Meng-Meng Wang
Rui-Min Xu
Wen-Lei Lv
Xian-Wei Ye
P2860
P304
P356
10.1021/JM401002R
P407
P577
2013-11-01T00:00:00Z