Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1
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Histone demethylase LSD1 controls the phenotypic plasticity of cancer cellsTherapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targetingEpigenomics of leukemia: from mechanisms to therapeutic applicationsThe role of histone demethylases in cancer therapyHistone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and preventionKDM1 class flavin-dependent protein lysine demethylasesLSD1 inhibition: a therapeutic strategy in cancer?Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural featuresThe lysine specific demethylase-1 (LSD1/KDM1A) regulates VEGF-A expression in prostate cancerImpairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor.Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectivesTLR ligands, but not modulators of histone modifiers, can induce the complex immune response pattern of endotoxin tolerance in mammary epithelial cells.Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1).Targeting histone lysine demethylases - progress, challenges, and the futureStructural insights into histone lysine demethylation.MiR137 is an androgen regulated repressor of an extended network of transcriptional coregulators.Small-molecular modulators of cancer-associated epigenetic mechanisms.Lysine-specific demethylase 1-selective inactivators: protein-targeted drug delivery mechanism.Identification of Novel Selective Lysine-Specific Demethylase 1 (LSD1) Inhibitors Using a Pharmacophore-Based Virtual Screening Combined with Docking.Targeting protein lysine methylation and demethylation in cancers.Brain-penetrant LSD1 inhibitors can block memory consolidation.Lysine-specific demethylase 1 mediates epidermal growth factor signaling to promote cell migration in ovarian cancer cells.Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners.3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1.Inhibition of Lysine-Specific Demethylase-1 (LSD1/KDM1A) Promotes the Adipogenic Differentiation of hESCs Through H3K4 Methylation.Chromatin-modifying agents for epigenetic reprogramming and endogenous neural stem cell-mediated repair in stroke.Triazole-dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration.Chemical biology of lysine demethylases.An overview of phenylcyclopropylamine derivatives: biochemical and biological significance and recent developments.The promise and failures of epigenetic therapies for cancer treatmentSmall molecule epigenetic inhibitors targeted to histone lysine methyltransferases and demethylases.Epigenetic regulation of cell signaling pathways in acute lymphoblastic leukemia.Histone lysine demethylases as targets for anticancer therapy.Epigenetic molecular recognition: a biomolecular modeling perspective.Reversible inhibitors of LSD1 as therapeutic agents in acute myeloid leukemia: clinical significance and progress to date.Targeting Histone Demethylases: A New Avenue for the Fight against Cancer.Inhibitors of emerging epigenetic targets for cancer therapy: a patent review (2010-2014).Using zebrafish as a model to study the role of epigenetics in hearing loss.Transcriptional Selectivity of Epigenetic Therapy in Cancer.Inhibitors of Protein Methyltransferases and Demethylases.
P2860
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P2860
Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Structurally designed trans-2- ...... histone demethylase LSD1/KDM1
@ast
Structurally designed trans-2- ...... histone demethylase LSD1/KDM1
@en
Structurally designed trans-2- ...... histone demethylase LSD1/KDM1
@nl
type
label
Structurally designed trans-2- ...... histone demethylase LSD1/KDM1
@ast
Structurally designed trans-2- ...... histone demethylase LSD1/KDM1
@en
Structurally designed trans-2- ...... histone demethylase LSD1/KDM1
@nl
prefLabel
Structurally designed trans-2- ...... histone demethylase LSD1/KDM1
@ast
Structurally designed trans-2- ...... histone demethylase LSD1/KDM1
@en
Structurally designed trans-2- ...... histone demethylase LSD1/KDM1
@nl
P50
P3181
P356
P1433
P1476
Structurally designed trans-2- ...... histone demethylase LSD1/KDM1
@en
P2093
Shinya Mimasu
P304
P3181
P356
10.1021/BI100299R
P407
P577
2010-08-03T00:00:00Z