Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model.
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Acetyl-CoA the key factor for survival or death of cholinergic neurons in course of neurodegenerative diseasesThiamine triphosphate synthesis in rat brain occurs in mitochondria and is coupled to the respiratory chainPeriodontal disease's contribution to Alzheimer's disease progression in Down syndromeThiamin diphosphate-dependent enzymes: from enzymology to metabolic regulation, drug design and disease modelsMitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition.The effect of thiamine deficiency on inflammation, oxidative stress and cellular migration in an experimental model of sepsisRecruiting adaptive cellular stress responses for successful brain ageing.Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease.Gene-environment interaction research and transgenic mouse models of Alzheimer's disease.Vascular and metabolic dysfunction in Alzheimer's disease: a review.Abnormal thiamine-dependent processes in Alzheimer's Disease. Lessons from diabetesReliability and validity of food frequency questionnaire and nutrient biomarkers in elders with and without mild cognitive impairment.Apomorphine and Alzheimer Aβ: roles for regulated α cleavage, autophagy, and antioxidation?A mitocentric view of Alzheimer's disease suggests multi-faceted treatmentsMitochondria and antioxidant targeted therapeutic strategies for Alzheimer's disease.Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging.The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease.Pathology supported genetic testing and treatment of cardiovascular disease in middle age for prevention of Alzheimer's disease.Longitudinal modeling of cognitive aging and the TOMM40 effect.Abnormal Glucose Metabolism in Alzheimer's Disease: Relation to Autophagy/Mitophagy and Therapeutic ApproachesMeasurement of Blood Thiamine Metabolites for Alzheimer's Disease Diagnosis.Vitamin B1 (thiamine) and dementiaOxidant-induced changes in mitochondria and calcium dynamics in the pathophysiology of Alzheimer's disease.Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases.Oxidative stress in Alzheimer's disease: why did antioxidant therapy fail?Role of thiamine in Alzheimer's disease.Diet, nutrients and metabolism: cogs in the wheel driving Alzheimer's disease pathology?Brain [U-13 C]glucose metabolism in mice with decreased α-ketoglutarate dehydrogenase complex activity.Loss of Mitochondrial Function Impairs Lysosomes.Alzheimer's Disease Risk Genes and Lipid Regulators.Thiamine Deficiency and Neurodegeneration: the Interplay Among Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy.Alcohol and Alzheimer's Disease-Does Alcohol Dependence Contribute to Beta-Amyloid Deposition, Neuroinflammation and Neurodegeneration in Alzheimer's Disease?Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulationMild reduction in the activity of the alpha-ketoglutarate dehydrogenase complex elevates GABA shunt and glycolysis.Translocation of amyloid precursor protein C-terminal fragment(s) to the nucleus precedes neuronal death due to thiamine deficiency-induced mild impairment of oxidative metabolism.Mitochondrial Impairment May Increase Cellular NAD(P)H: Resazurin Oxidoreductase Activity, Perturbing the NAD(P)H-Based Viability Assays.Thiamine antagonists trigger p53-dependent apoptosis in differentiated SH-SY5Y cellsAblation of the locus coeruleus increases oxidative stress in tg-2576 transgenic but not wild-type mice.Interactions of endoplasmic reticulum and mitochondria Ca(2+) stores with capacitative calcium entry.Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice.
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P2860
Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 10 April 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Thiamine deficiency induces ox ...... gy in Alzheimer's mouse model.
@en
Thiamine deficiency induces ox ...... gy in Alzheimer's mouse model.
@nl
type
label
Thiamine deficiency induces ox ...... gy in Alzheimer's mouse model.
@en
Thiamine deficiency induces ox ...... gy in Alzheimer's mouse model.
@nl
prefLabel
Thiamine deficiency induces ox ...... gy in Alzheimer's mouse model.
@en
Thiamine deficiency induces ox ...... gy in Alzheimer's mouse model.
@nl
P2093
P2860
P1476
Thiamine deficiency induces ox ...... gy in Alzheimer's mouse model.
@en
P2093
David Pechman
Gary E Gibson
Harriet Baker
Lian H Chen
M Flint Beal
Qingli Shi
Sam E Gandy
Saravanan S Karuppagounder
Steve Pedrini
P2860
P304
P356
10.1016/J.NEUROBIOLAGING.2007.12.013
P577
2008-04-10T00:00:00Z