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ITM2A is induced during thymocyte selection and T cell activation and causes downregulation of CD8 when overexpressed in CD4(+)CD8(+) double positive thymocytesHuman immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabetaDevelopment of thymically derived natural regulatory T cells.Phenotypic and functional evaluation of CD3+CD4-CD8- T cells in human CD8 immunodeficiency.MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis.Familial CD8 deficiency due to a mutation in the CD8 alpha gene.HD mice: a novel mouse mutant with a specific defect in the generation of CD4(+) T cells.A constant affinity threshold for T cell tolerance.CD8 expression up to the double-positive CD3(low/intermediate) stage of thymic differentiation is sufficient for development of peripheral functional cytotoxic T lymphocytes.CD3 ligation on immature thymocytes generates antagonist-like signals appropriate for CD8 lineage commitment, independently of T cell receptor specificity.An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II-restricted T cells in the absence of CD4On the logic of positive selection.Generation of antiviral major histocompatibility complex class I-restricted T cells in the absence of CD8 coreceptors.The T cell receptor's alpha-chain connecting peptide motif promotes close approximation of the CD8 coreceptor allowing efficient signal initiationDuality of the murine CD8 compartment.How the TCR balances sensitivity and specificity for the recognition of self and pathogens.Thoughts on Positive Selection in Thymus.A single peptide-MHC complex positively selects a diverse and specific CD8 T cell repertoireDown-modulation of CD8αβ is a fundamental activity of primate lentiviral Nef proteins.Rescue of cytotoxic function in the CD8alpha knockout mouse by removal of MHC class II.Lipid-mediated presentation of MHC class II molecules guides thymocytes to the CD4 lineage.T-cell fate.Natural killer cells play a critical role in the immune response following immunization with melanoma-antigen-engineered dendritic cells.The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment.A molecular chart of thymocyte positive selection.CD4/CD8 lineage commitment: matching fate with competence.Molecular requirements for lineage commitment in the thymus--antibody-mediated receptor engagements reveal a central role for lck in lineage decisions.Thymocyte selection: not by TCR alone.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 1997
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
CD8 lineage commitment in the absence of CD8.
@en
CD8 lineage commitment in the absence of CD8.
@nl
type
label
CD8 lineage commitment in the absence of CD8.
@en
CD8 lineage commitment in the absence of CD8.
@nl
prefLabel
CD8 lineage commitment in the absence of CD8.
@en
CD8 lineage commitment in the absence of CD8.
@nl
P2860
P1433
P1476
CD8 lineage commitment in the absence of CD8
@en
P2093
A W Goldrath
P2860
P304
P356
10.1016/S1074-7613(00)80351-9
P407
P577
1997-05-01T00:00:00Z