Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs. - Wikidata - awgldk - TriplyDB

Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs.

Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs.

http://www.wikidata.org/entity/Q37439765

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An integrative computational systems biology approach identifies differentially regulated dynamic transcriptome signatures which drive the initiation of human T helper cell differentiation Structural basis of substrate discrimination and integrin binding by autotaxin Leukocyte integrins: role in leukocyte recruitment and as therapeutic targets in inflammatory disease Understanding high endothelial venules: Lessons for cancer immunology Regulation of T cell motility in vitro and in vivo by LPA and LPA2 p100 Deficiency is insufficient for full activation of the alternative NF-κB pathway: TNF cooperates with p52-RelB in target gene transcription Structural basis for specific inhibition of Autotaxin by a DNA aptamer Autotaxin: structure-function and signaling Novel point mutations attenuate autotaxin activity Integrin-mediated cell surface recruitment of autotaxin promotes persistent directional cell migration.Differential RelA- and RelB-dependent gene transcription in LTbetaR-stimulated mouse embryonic fibroblasts Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation.Noninvasive tracking of donor cell homing by near-infrared fluorescence imaging shortly after bone marrow transplantation Identification of heparin-binding EGF-like growth factor (HB-EGF) as a biomarker for lysophosphatidic acid receptor type 1 (LPA1) activation in human breast and prostate cancers.LPA induces IL-6 secretion from aortic smooth muscle cells via an LPA1-regulated, PKC-dependent, and p38alpha-mediated pathway Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis.LPA receptor signaling: pharmacology, physiology, and pathophysiology.Cellular function and molecular structure of ecto-nucleotidases.Crystallization and preliminary X-ray diffraction analysis of rat autotaxin.Autotaxin-lysophosphatidic acid signaling axis mediates tumorigenesis and development of acquired resistance to sunitinib in renal cell carcinoma.Aiming drug discovery at lysophosphatidic acid targets.Activation of fibroblast-like synoviocytes derived from rheumatoid arthritis via lysophosphatidic acid-lysophosphatidic acid receptor 1 cascade Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to bone.TNF-alpha promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines.Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells.LPA-producing enzyme PA-PLA₁α regulates hair follicle development by modulating EGFR signalling.Diverse roles of LPA signaling in the intestinal epithelium.Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors.Phospholipase D: enzymology, functionality, and chemical modulation Type I Interferons Function as Autocrine and Paracrine Factors to Induce Autotaxin in Response to TLR Activation.Lpa2 is a negative regulator of both dendritic cell activation and murine models of allergic lung inflammation.Chemical evolution of autotaxin inhibitors LPA Promotes T Cell Recruitment through Synthesis of CXCL13.Microenvironmental Control of High-Speed Interstitial T Cell Migration in the Lymph Node.Autotaxin/ENPP2 regulates oligodendrocyte differentiation in vivo in the developing zebrafish hindbrain.T Cell Motility as Modulator of Interactions with Dendritic Cells Autotaxin, a lysophospholipase D with pleomorphic effects in oncogenesis and cancer progression A map of the distribution of sphingosine 1-phosphate in the spleen Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility.

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Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs.

http://www.wikidata.org/entity/Q37439765

description

article científic

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article scientifique

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bilimsel makale

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scientific article published on 09 March 2008

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Autotaxin, an ectoenzyme that ...... nto secondary lymphoid organs.

@en

Autotaxin, an ectoenzyme that ...... nto secondary lymphoid organs.

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Autotaxin, an ectoenzyme that ...... nto secondary lymphoid organs.

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Autotaxin, an ectoenzyme that ...... nto secondary lymphoid organs.

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Autotaxin, an ectoenzyme that ...... nto secondary lymphoid organs.

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Autotaxin, an ectoenzyme that ...... nto secondary lymphoid organs.

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Nature Immunology

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Autotaxin, an ectoenzyme that ...... nto secondary lymphoid organs.

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Hidenobu Kanda

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Michael D Gunn

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Rebecca Newton

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Russell Klein

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Steven D Rosen

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Yuka Morita

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P2860

Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin

Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein

cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases

Par-1 promotes a hepatic mode of apical protein trafficking in MDCK cells

Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)

Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces

Altered expression and functional profile of lysophosphatidic acid receptors in mitogen-activated human blood T lymphocytes

An endothelial ligand for L-selectin is a novel mucin-like molecule

The emerging role of lysophosphatidic acid in cancer

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scholarly article

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10.1038/NI1573

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4

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9

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2008-03-09T00:00:00Z

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1043521298

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18327261

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2783613

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