Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins.
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Protein Folding and Mechanisms of ProteostasisCytoplasmic mRNA turnover and ageingLegal but lethal: functional protein aggregation at the verge of toxicityComparison of the aggregation of homologous β2-microglobulin variants reveals protein solubility as a key determinant of amyloid formationAre aberrant phase transitions a driver of cellular aging?Nucleus factory on cavitation bubble for amyloid β fibril.Supersaturation-limited amyloid fibrillation of insulin revealed by ultrasonication.Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose).Heat of supersaturation-limited amyloid burst directly monitored by isothermal titration calorimetry.Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS.TR-FRET assays of Huntingtin protein fragments reveal temperature and polyQ length-dependent conformational changes.Protein homeostasis of a metastable subproteome associated with Alzheimer's disease.Biophysics of protein evolution and evolutionary protein biophysicsGlobal analysis of protein aggregation in yeast during physiological conditions and arsenite stress.Widespread Proteome Remodeling and Aggregation in Aging C. elegans.Patterns of gene expression associated with recovery and injury in heat-stressed rats.The H50Q mutation induces a 10-fold decrease in the solubility of α-synuclein.Structural and kinetic analysis of protein-aggregate strains in vivo using binary epitope mappingThe OPEP protein model: from single molecules, amyloid formation, crowding and hydrodynamics to DNA/RNA systemsOptimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity.Supersaturation-limited and Unlimited Phase Transitions Compete to Produce the Pathway Complexity in Amyloid Fibrillation.Protein aggregation, structural disorder and RNA-binding ability: a new approach for physico-chemical and gene ontology classification of multiple datasets.SOD1 aggregation in ALS mice shows simplistic test tube behavior.Thermodynamics of protein destabilization in live cellsSingle-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids.A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregationDiscovery of protein-RNA networks.Small heat-shock proteins: important players in regulating cellular proteostasis.Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases.Walking the tightrope: proteostasis and neurodegenerative disease.Universality of supersaturation in protein-fiber formation.Molecular Pathophysiology of Fragile X-Associated Tremor/Ataxia Syndrome and Perspectives for Drug Development.Understanding and predicting protein misfolding and aggregation: Insights from proteomics.The yin and yang of amyloid aggregation.When proteostasis goes bad: Protein aggregation in the cell.Distinct stress conditions result in aggregation of proteins with similar properties.Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics.Amyloid-like Fibrils from an α-Helical Transmembrane Protein.Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation.Diffusion within the cytoplasm: a mesoscale model of interacting macromolecules
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Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 31 October 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Widespread aggregation and neu ...... with supersaturated proteins.
@en
Widespread aggregation and neu ...... with supersaturated proteins.
@nl
type
label
Widespread aggregation and neu ...... with supersaturated proteins.
@en
Widespread aggregation and neu ...... with supersaturated proteins.
@nl
prefLabel
Widespread aggregation and neu ...... with supersaturated proteins.
@en
Widespread aggregation and neu ...... with supersaturated proteins.
@nl
P2860
P50
P1433
P1476
Widespread aggregation and neu ...... with supersaturated proteins.
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P2093
Prajwal Ciryam
Richard I Morimoto
P2860
P304
P356
10.1016/J.CELREP.2013.09.043
P577
2013-10-31T00:00:00Z