cAMP signal transduction in the heart: understanding spatial control for the development of novel therapeutic strategies.
about
Imaging alterations of cardiomyocyte cAMP microdomains in diseaseStudying GPCR/cAMP pharmacology from the perspective of cellular structureSpatial control of cAMP signalling in health and diseaseIntracellular cAMP signaling by soluble adenylyl cyclase.New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP efflux and extracellular cAMP-adenosine pathwayCyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heartCyclic AMP control measured in two compartments in HEK293 cells: phosphodiesterase K(M) is more important than phosphodiesterase localizationcGMP Signals Modulate cAMP Levels in a Compartment-Specific Manner to Regulate Catecholamine-Dependent Signaling in Cardiac MyocytesFRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility.Cardiac troponin T, a sarcomeric AKAP, tethers protein kinase A at the myofilaments.Soluble adenylyl cyclase is necessary and sufficient to overcome the block of axonal growth by myelin-associated factors.Cardiac cyclic nucleotide phosphodiesterases: function, regulation, and therapeutic prospects.Physiological sensing of carbon dioxide/bicarbonate/pH via cyclic nucleotide signaling.The high-affinity phosphodiesterase BcPde2 has impact on growth, differentiation and virulence of the phytopathogenic ascomycete Botrytis cinereaRegulation of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2.UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy.AKAPs: the architectural underpinnings of local cAMP signaling.Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domainsThe matricellular protein thrombospondin-1 globally regulates cardiovascular function and responses to stress via CD47.Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.Role of soluble adenylyl cyclase in the heart.Compartmentalization of beta-adrenergic signals in cardiomyocytes.PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome.Conservation and divergence of the cyclic adenosine monophosphate-protein kinase A (cAMP-PKA) pathway in two plant-pathogenic fungi: Fusarium graminearum and F. verticillioides.A novel biosensor to study cAMP dynamics in cilia and flagellaSeparate roles of PKA and EPAC in renal function unraveled by the optogenetic control of cAMP levels in vivoLocal modulation of cystic fibrosis conductance regulator: cytoskeleton and compartmentalized cAMP signalling.Interactions of Calcium Fluctuations during Cardiomyocyte Contraction with Real-Time cAMP Dynamics Detected by FRET.Established and potential physiological roles of bicarbonate-sensing soluble adenylyl cyclase (sAC) in aquatic animals.A-kinase anchoring proteins: getting to the heart of the matter.Compartmentation of membrane processes and nucleotide dynamics in diffusion-restricted cardiac cell microenvironment.Biological roles of cAMP: variations on a theme in the different kingdoms of life.Compartmentation of cAMP signalling in cardiomyocytes in health and disease.Biophysical techniques for detection of cAMP and cGMP in living cells.Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.cAMP signaling in subcellular compartments.Cyclic AMP reverses the effects of aging on pacemaker activity and If in sinoatrial node myocytesModeling calcium regulation of contraction, energetics, signaling, and transcription in the cardiac myocyte.Localized signals that regulate transendothelial migration.Cardiac Phosphodiesterases and Their Modulation for Treating Heart Disease.
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P2860
cAMP signal transduction in the heart: understanding spatial control for the development of novel therapeutic strategies.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 09 April 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
cAMP signal transduction in th ...... novel therapeutic strategies.
@en
cAMP signal transduction in th ...... novel therapeutic strategies.
@nl
type
label
cAMP signal transduction in th ...... novel therapeutic strategies.
@en
cAMP signal transduction in th ...... novel therapeutic strategies.
@nl
prefLabel
cAMP signal transduction in th ...... novel therapeutic strategies.
@en
cAMP signal transduction in th ...... novel therapeutic strategies.
@nl
P2860
P1476
cAMP signal transduction in th ...... novel therapeutic strategies.
@en
P2860
P356
10.1111/J.1476-5381.2009.00185.X
P407
P577
2009-04-09T00:00:00Z