Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel
about
Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activityMutation of an A-kinase-anchoring protein causes long-QT syndromeThe KCNQ1 (Kv7.1) COOH terminus, a multitiered scaffold for subunit assembly and protein interactionO-glycosylation of the cardiac I(Ks) complexPhosphorylation of the A-kinase-anchoring protein Yotiao contributes to protein kinase A regulation of a heart potassium channelA KCNQ1 mutation contributes to the concealed type 1 long QT phenotype by limiting the Kv7.1 channel conformational changes associated with protein kinase A phosphorylationObscurin targets ankyrin-B and protein phosphatase 2A to the cardiac M-lineAn anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamicsOestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epitheliumIntracellular domains interactions and gated motions of I(KS) potassium channel subunitsA carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly.Bigger, better, faster: principles and models of AKAP anchoring protein signaling.Structural insight into KCNQ (Kv7) channel assembly and channelopathyKCNE variants reveal a critical role of the beta subunit carboxyl terminus in PKA-dependent regulation of the IKs potassium channelDynamic partnership between KCNQ1 and KCNE1 and influence on cardiac IKs current amplitude by KCNE2Inactivation as a new regulatory mechanism for neuronal Kv7 channelsAmino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphismCounteracting Protein Kinase Activity in the Heart: The Multiple Roles of Protein PhosphatasesGenetics of inherited primary arrhythmia disordersCaV1.2 signaling complexes in the heartIon Channels in the HeartDefective interactions of protein partner with ion channels and transporters as alternative mechanisms of membrane channelopathiesThe KCNQ1 channel - remarkable flexibility in gating allows for functional versatilityDriving with no brakes: molecular pathophysiology of Kv7 potassium channelsX-ray Crystal Structure of a TRPM Assembly Domain Reveals an Antiparallel Four-stranded Coiled-coilCrystal structure of a trimeric form of the KV7.1 (KCNQ1) A-domain tail coiled-coil reveals structural plasticity and context dependent changes in a putative coiled-coil trimerization motifMolecular mechanism for 3:1 subunit stoichiometry of rod cyclic nucleotide-gated ion channelsIntracellular cAMP signaling by soluble adenylyl cyclase.Role of serine-threonine phosphoprotein phosphatases in smooth muscle contractilityMolecular pathogenesis of long QT syndrome type 1Ion channel macromolecular complexes in cardiomyocytes: roles in sudden cardiac deathMolecular basis for PP2A regulatory subunit B56alpha targeting in cardiomyocytesAssembly of a Ca2+-dependent BK channel signaling complex by binding to beta2 adrenergic receptorAKAP150 signaling complex promotes suppression of the M-current by muscarinic agonistsAKAP-Lbc mobilizes a cardiac hypertrophy signaling pathwayDopamine modulation of neuronal Na(+) channels requires binding of A kinase-anchoring protein 15 and PKA by a modified leucine zipper motifBeta-adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15The A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in brainIdentification of rare DNA sequence variants in high-risk autism families and their prevalence in a large case/control population
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P248
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P2860
Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel
description
2002 nî lūn-bûn
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2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Requirement of a macromolecula ...... KCNQ1-KCNE1 potassium channel
@ast
Requirement of a macromolecula ...... KCNQ1-KCNE1 potassium channel
@en
Requirement of a macromolecula ...... KCNQ1-KCNE1 potassium channel
@en-gb
Requirement of a macromolecula ...... KCNQ1-KCNE1 potassium channel
@nl
type
label
Requirement of a macromolecula ...... KCNQ1-KCNE1 potassium channel
@ast
Requirement of a macromolecula ...... KCNQ1-KCNE1 potassium channel
@en
Requirement of a macromolecula ...... KCNQ1-KCNE1 potassium channel
@en-gb
Requirement of a macromolecula ...... KCNQ1-KCNE1 potassium channel
@nl
prefLabel
Requirement of a macromolecula ...... KCNQ1-KCNE1 potassium channel
@ast
Requirement of a macromolecula ...... KCNQ1-KCNE1 potassium channel
@en
Requirement of a macromolecula ...... KCNQ1-KCNE1 potassium channel
@en-gb
Requirement of a macromolecula ...... KCNQ1-KCNE1 potassium channel
@nl
P2093
P921
P3181
P356
P1433
P1476
Requirement of a macromolecula ...... KCNQ1-KCNE1 potassium channel
@en
P2093
Andrew R Marks
Howard Motoike
Jeanine D'Armiento
Robert S Kass
Steven O Marx
Steven Reiken
P3181
P356
10.1126/SCIENCE.1066843
P407
P577
2002-01-18T00:00:00Z