Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding.
about
Does Diacylglycerol Accumulation in Fatty Liver Disease Cause Hepatic Insulin Resistance?Intestinal triacylglycerol synthesis in fat absorption and systemic energy metabolismOver-expression of monoacylglycerol lipase (MGL) in small intestine alters endocannabinoid levels and whole body energy balance, resulting in obesityIdentification of Yju3p as functional orthologue of mammalian monoglyceride lipase in the yeast Saccharomycescerevisiae.Carboxylesterase1/Esterase-x regulates chylomicron production in micePharmacological Inhibition of Monoacylglycerol O-Acyltransferase 2 Improves Hyperlipidemia, Obesity, and Diabetes by Change in Intestinal Fat UtilizationThe biogenesis of chylomicronsNocturnin regulates circadian trafficking of dietary lipid in intestinal enterocytes.Hepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes.Monoacylglycerol acyltransferase-2 is a tetrameric enzyme that selectively heterodimerizes with diacylglycerol acyltransferase-1.Abrogating monoacylglycerol acyltransferase activity in liver improves glucose tolerance and hepatic insulin signaling in obese mice.Intestine-specific deletion of acyl-CoA:monoacylglycerol acyltransferase (MGAT) 2 protects mice from diet-induced obesity and glucose intolerance.Intestine-specific expression of acyl CoA:diacylglycerol acyltransferase 1 reverses resistance to diet-induced hepatic steatosis and obesity in Dgat1-/- miceNovel acyl-coenzyme A:monoacylglycerol acyltransferase plays an important role in hepatic triacylglycerol secretion.MGAT2 deficiency and vertical sleeve gastrectomy have independent metabolic effects in the mouse.Physiological roles of group X-secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function.Obesity, longevity, quality of life: alteration by dietary 2-mercaptoethanol.Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance.Adult-onset deficiency of acyl CoA:monoacylglycerol acyltransferase 2 protects mice from diet-induced obesity and glucose intoleranceIntestinal acyl-CoA:diacylglycerol acyltransferase 2 overexpression enhances postprandial triglyceridemic response and exacerbates high fat diet-induced hepatic triacylglycerol storageDeficiency of MGAT2 increases energy expenditure without high-fat feeding and protects genetically obese mice from excessive weight gain.Role of the gut in modulating lipoprotein metabolism.Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signalingHepatic fatty acid uptake is regulated by the sphingolipid acyl chain length.Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity.Glycerol-3-phosphate Acyltransferase Isoform-4 (GPAT4) Limits Oxidation of Exogenous Fatty Acids in Brown AdipocytesGut triglyceride production.Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver.Regulation of lipid metabolism-related gene expression in whole blood cells of normo- and dyslipidemic men after fish oil supplementation.Characterization of a Novel Intestinal Glycerol-3-phosphate Acyltransferase Pathway and Its Role in Lipid HomeostasisRole of the gut in lipid homeostasisIntestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat DietSimulation of triacylglycerol ion profiles: bioinformatics for interpretation of triacylglycerol biosynthesis.Intestine-specific expression of MOGAT2 partially restores metabolic efficiency in Mogat2-deficient mice.Evidence for a role of LPGAT1 in influencing BMI and percent body fat in Native Americans.Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice.Direct comparison of mice null for liver or intestinal fatty acid-binding proteins reveals highly divergent phenotypic responses to high fat feeding.Dietary fat sensing via fatty acid oxidation in enterocytes: possible role in the control of eating.Gut-brain signalling: how lipids can trigger the gut.Gut-liver interaction in triglyceride-rich lipoprotein metabolism.
P2860
Q26798161-FADD7FE2-B0C4-4C66-A8A0-479B40634BAEQ27023275-174BC7FB-462C-4DC4-A7FF-6FB73A254209Q27321622-32C1DF2E-29D3-4294-B67B-35DB1E7BEDE4Q27936792-A6C297DB-BFBB-4199-810D-6CEAABDA23DCQ28484918-23FE6D1F-09D6-4F98-8870-64C81DE4218AQ28550545-25422D0F-B10F-4C04-82FD-96A8D5ED5212Q28833221-5BE32420-BDFA-4FC1-B87B-E02BEED689D7Q30425427-F9AADB68-FDE4-4D3C-959E-5802A5055CB7Q33637226-E2C26A04-48C7-42E4-A82C-2B1FA339ABE1Q33675926-80BD84A1-600C-4831-BC74-076AF714750EQ33789323-AB9EE043-AB12-465C-8542-42A220501EEEQ33792850-645C39D3-FB40-4468-ADEC-1FCB1F2D1F84Q33902090-B9800444-2E43-4827-A17B-08AF1A26B926Q34559896-74D3EB57-3042-4CEB-8657-6A741A8B0C03Q34627645-91E52010-5348-4D98-BBFD-9B40461D7E85Q34719758-E6F068C3-8A78-48FD-A442-20A32C9C0F73Q34775737-2E0F9DF0-12AD-4DEA-A88F-DF5D185C1EE3Q34978868-4BADD1A3-3852-4AD3-A27D-884D10942B73Q35014285-40661497-06C9-4564-925B-09470E46F19CQ35030629-C9FC3408-0279-40B2-9B79-F7EDD7E814AAQ35152233-46EDF4AD-915E-44F5-A836-E1F8E19C4403Q35192357-EAC34D2B-BB4E-4666-B3D8-45C2AC39F072Q35235426-59908269-D06A-47BF-AE34-4C355425AA96Q35522279-4313C2D3-BDEE-4972-9B1D-5CF8B21A64F6Q35642904-76359FA3-553C-45F8-AAAA-47F1BDDA53ACQ35721817-9644B960-6EA6-496B-9832-3CA5ECA0E14CQ35870227-EE973D3D-D5AC-4A79-90E2-1630AB4295C1Q35897072-79CB6F74-D138-44C2-9CDC-D96D4BD619E9Q36527069-B78973FC-C05B-4BA8-B76B-87BFCBD68825Q36548331-F3A70248-3D89-498A-ACF4-081B2268011DQ36660888-303A3A01-4F36-4078-B86D-695D1E2CA31CQ36669757-345EBD8F-2EF4-4D8A-9AE8-6C129D2F7DD8Q36709577-3303904A-E42F-4F96-87FC-F27FF194EDD5Q36822585-7009424D-C1F6-43B3-8283-31F68A508F8BQ36882283-5DB22C16-834D-4770-8ECD-D93ABFBD1D66Q37139415-242FE51B-5591-4DA0-A4F7-478512595F5EQ37234028-8CA79ECF-2A93-4DDF-8424-610A27C086C6Q37819529-37562325-F70A-4757-8053-8FA8F7416EADQ37835787-17F2AD5D-9E59-4C3D-8AA9-663E74E8F4E0Q37892758-FD86B7F1-6732-47C6-8BCB-42F390D1DDE2
P2860
Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 15 March 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Deficiency of the intestinal e ...... s induced by high-fat feeding.
@en
Deficiency of the intestinal e ...... s induced by high-fat feeding.
@nl
type
label
Deficiency of the intestinal e ...... s induced by high-fat feeding.
@en
Deficiency of the intestinal e ...... s induced by high-fat feeding.
@nl
prefLabel
Deficiency of the intestinal e ...... s induced by high-fat feeding.
@en
Deficiency of the intestinal e ...... s induced by high-fat feeding.
@nl
P2093
P2860
P356
P1433
P1476
Deficiency of the intestinal e ...... rs induced by high-fat feeding
@en
P2093
Brian Hubbard
Chi-Liang Eric Yen
Jinny S Wong
Junya Moriwaki
Mei-Leng Cheong
Robert V Farese
Stephen Marmor
P2860
P2888
P304
P356
10.1038/NM.1937
P407
P577
2009-03-15T00:00:00Z