Centromere replication timing determines different forms of genomic instability in Saccharomyces cerevisiae checkpoint mutants during replication stress.
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Managing Single-Stranded DNA during Replication Stress in Fission YeastRif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complexThe network architecture of the Saccharomyces cerevisiae genome.Hydroxyurea exposure triggers tissue-specific activation of p38 mitogen-activated protein kinase signaling and the DNA damage response in organogenesis-stage mouse embryos.One-hit wonders of genomic instability.Functional centromeres determine the activation time of pericentric origins of DNA replication in Saccharomyces cerevisiae.Separation of DNA replication from the assembly of break-competent meiotic chromosomes.Topoisomerase II- and condensin-dependent breakage of MEC1ATR-sensitive fragile sites occurs independently of spindle tension, anaphase, or cytokinesis.Characterization of chromosome stability in diploid, polyploid and hybrid yeast cellsBreak-seq reveals hydroxyurea-induced chromosome fragility as a result of unscheduled conflict between DNA replication and transcriptionReplication stress-induced chromosome breakage is correlated with replication fork progression and is preceded by single-stranded DNA formationAccurate identification of centromere locations in yeast genomes using Hi-C.The yeast genome undergoes significant topological reorganization in quiescence.RAD53 is limiting in double-strand break repair and in protection against toxicity associated with ribonucleotide reductase inhibitionNucleotide-resolution DNA double-strand break mapping by next-generation sequencing.DNA replication and spindle checkpoints cooperate during S phase to delay mitosis and preserve genome integrityThe CINs of the centromere.Mec1/ATR, the Program Manager of Nucleic Acids Inc.Molecular analysis of the replication program in unicellular model organisms.Centromere Stability: The Replication Connection.dNTP pools determine fork progression and origin usage under replication stress.A role for the spindle assembly checkpoint in the DNA damage response.Analysis of replication timing using synchronized budding yeast cultures.G(1)/S and G(2)/M cyclin-dependent kinase activities commit cells to death in the absence of the S-phase checkpoint.Conservation of replication timing reveals global and local regulation of replication origin activity.Checkpoint-dependent RNR induction promotes fork restart after replicative stress.
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P2860
Centromere replication timing determines different forms of genomic instability in Saccharomyces cerevisiae checkpoint mutants during replication stress.
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article científic
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article scientifique
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artigo científico
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bilimsel makale
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scientific article published on 05 October 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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Centromere replication timing ...... nts during replication stress.
@en
Centromere replication timing ...... nts during replication stress.
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type
label
Centromere replication timing ...... nts during replication stress.
@en
Centromere replication timing ...... nts during replication stress.
@nl
prefLabel
Centromere replication timing ...... nts during replication stress.
@en
Centromere replication timing ...... nts during replication stress.
@nl
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P2860
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Centromere replication timing ...... nts during replication stress.
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Bonita J Brewer
David Collingwood
Jeff Bachant
M K Raghuraman
Wenyi Feng
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P304
P356
10.1534/GENETICS.109.107508
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2009-10-05T00:00:00Z