Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection. - Wikidata - awgldk - TriplyDB

Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection.

Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection.

http://www.wikidata.org/entity/Q37462991

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LGR4 and Its Role in Intestinal Protection and Energy Metabolism Emerging Treatment Paradigms in Radiation Oncology How to make an intestine TLR4/PKC-mediated tight junction modulation: a clinical marker of chemotherapy-induced gut toxicity?Radiation enteropathy--pathogenesis, treatment and prevention Krüppel-like factor 4 is a radioprotective factor for the intestine following γ-radiation-induced gut injury in mice.Coordinate regulation of stem cell competition by Slit-Robo and JAK-STAT signaling in the Drosophila testis.Rpb3 promotes hepatocellular carcinoma through its N-terminus.SLIT/ROBO2 signaling promotes mammary stem cell senescence by inhibiting Wnt signaling.miR-1179 promotes cell invasion through SLIT2/ROBO1 axis in esophageal squamous cell carcinoma.Engineering high-potency R-spondin adult stem cell growth factors.Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage.Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation Slit2/Robo1 signaling promotes intestinal tumorigenesis through Src-mediated activation of the Wnt/β-catenin pathway.Can we safely target the WNT pathway?Silencing of R-Spondin1 increases radiosensitivity of glioma cells.Phenotypic and Molecular Alterations in the Mammary Tissue of R-Spondin1 Knock-Out Mice during Pregnancy.Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine.Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration LIG4 mediates Wnt signalling-induced radioresistance.Quantitative trait gene Slit2 positively regulates murine hematopoietic stem cell numbers.POU2F2-oriented network promotes human gastric cancer metastasis.Mesenchymal stem cells stimulate intestinal stem cells to repair radiation-induced intestinal injury.RSPOs facilitated HSC activation and promoted hepatic fibrogenesis.SOX17 is a tumor suppressor in endometrial cancer New pharmacotherapy options for chemotherapy-induced alimentary mucositis.Management of Mucositis During Chemotherapy: From Pathophysiology to Pragmatic Therapeutics.Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo.N-glycosylation of R-spondin1 at Asn137 negatively regulates its secretion and Wnt/β-catenin signaling-enhancing activity.Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche.HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells.Trial Watch: Radioimmunotherapy for oncological indications.Casein kinase 1-epsilon or 1-delta required for Wnt-mediated intestinal stem cell maintenance.R-Spondin1/LGR5 Activates TGFβ Signaling and Suppresses Colon Cancer Metastasis.Defining key concepts of intestinal and epithelial cancer biology through the use of mouse models.Effects of a small molecule R-spondin-1 substitute RS-246204 on a mouse intestinal organoid culture.Robo and Ror function in a common receptor complex to regulate Wnt-mediated neurite outgrowth in Caenorhabditis elegans.Targeting p53-dependent stem cell loss for intestinal chemoprotection.Robo1 Forms a Compact Dimer-of-Dimers Assembly.The small GTPase ARF6 regulates protein trafficking to control cellular function during development and in disease.

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Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection.

http://www.wikidata.org/entity/Q37462991

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 31 July 2013

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

Induction of intestinal stem c ...... augments chemoradioprotection.

@en

Induction of intestinal stem c ...... augments chemoradioprotection.

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type

label

Induction of intestinal stem c ...... augments chemoradioprotection.

@en

Induction of intestinal stem c ...... augments chemoradioprotection.

@nl

prefLabel

Induction of intestinal stem c ...... augments chemoradioprotection.

@en

Induction of intestinal stem c ...... augments chemoradioprotection.

@nl

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Induction of intestinal stem c ...... augments chemoradioprotection.

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Jason R Spence

http://www.w3.org/2001/XMLSchema#string

Jian-Guo Geng

http://www.w3.org/2001/XMLSchema#string

Wei-Jie Zhou

http://www.w3.org/2001/XMLSchema#string

Zhen H Geng

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P2860

Hallmarks of Cancer: The Next Generation

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

P-selectin primes leukocyte integrin activation during inflammation

SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site

Wnt/β-catenin signaling and disease

Identification of stem cells in small intestine and colon by marker gene Lgr5

Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Conserved roles for Slit and Robo proteins in midline commissural axon guidance

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche.

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scholarly article

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10.1038/NATURE12416

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2013-07-31T00:00:00Z

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1051994484

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3888063

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