The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli
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TRP channels in neurogastroenterology: opportunities for therapeutic interventionInternational Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel familyTransient receptor potential (TRP) channels as drug targets for diseases of the digestive systemTRPA1 as a drug target--promise and challengesThe role of TRPA1 in visceral inflammation and painSmall molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain.Neurogenic inflammation after traumatic brain injury and its potentiation of classical inflammationNociceptive TRP Channels: Sensory Detectors and Transducers in Multiple Pain PathologiesInhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in miceDifferential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in MiceTRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed ratsActivation of TRPA1 by luminal stimuli induces EP4-mediated anion secretion in human and rat colonInterplay between mast cells, enterochromaffin cells, and sensory signaling in the aging human bowelTRPC1 contributes to light-touch sensation and mechanical responses in low-threshold cutaneous sensory neuronsMultiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1.Transient receptor potential ankyrin-1 has a major role in mediating visceral pain in mice.Expression of transient receptor potential channels and two-pore potassium channels in subtypes of vagal afferent neurons in ratIdentifying the Ion Channels Responsible for Signaling Gastro-Intestinal Based PainA-Kinase Anchoring Protein 79/150 Scaffolds Transient Receptor Potential A 1 Phosphorylation and Sensitization by Metabotropic Glutamate Receptor Activation.Contribution of transient receptor potential ankyrin 1 to chronic pain in aged mice with complete Freund's adjuvant-induced arthritis.Chemo-nociceptive signalling from the colon is enhanced by mild colitis and blocked by inhibition of transient receptor potential ankyrin 1 channels.Molecular mechanisms of mechanotransduction in mammalian sensory neurons.The dynamic TRPA1 channel: a suitable pharmacological pain target?TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins.TRPA1 has a key role in the somatic pro-nociceptive actions of hydrogen sulfideA Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer PainCharacterization of silent afferents in the pelvic and splanchnic innervations of the mouse colorectumEpithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin upregulates blood flow in rat small intestine.Identification of the visceral pain pathway activated by noxious colorectal distension in mice.Capsaicin-responsive corneal afferents do not contain TRPV1 at their central terminals in trigeminal nucleus caudalis in ratsModulation of visceral hypersensitivity by glial cell line-derived neurotrophic factor family receptor α-3 in colorectal afferents.Metabotropic glutamate receptors as novel therapeutic targets on visceral sensory pathways.Differences in the expression of transient receptor potential channel V1, transient receptor potential channel A1 and mechanosensitive two pore-domain K+ channels between the lumbar splanchnic and pelvic nerve innervations of mouse urinary bladder aColitis decreases mechanosensitive K2P channel expression and function in mouse colon sensory neuronsTRP channels in the digestive systemTRPV4 as a therapeutic target for joint diseases.Mechanosensory and ATP Release Deficits following Keratin14-Cre-Mediated TRPA1 Deletion Despite Absence of TRPA1 in Murine KeratinocytesIrritable bowel syndrome: methods, mechanisms, and pathophysiology. Neural and neuro-immune mechanisms of visceral hypersensitivity in irritable bowel syndrome.Sex differences in spinal processing of transient and inflammatory colorectal stimuli in the ratLuminal hypertonicity and acidity modulate colorectal afferents and induce persistent visceral hypersensitivity.
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The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 24 July 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The ion channel TRPA1 is requi ...... s modulated by algesic stimuli
@en
The ion channel TRPA1 is requi ...... modulated by algesic stimuli.
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type
label
The ion channel TRPA1 is requi ...... s modulated by algesic stimuli
@en
The ion channel TRPA1 is requi ...... modulated by algesic stimuli.
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prefLabel
The ion channel TRPA1 is requi ...... s modulated by algesic stimuli
@en
The ion channel TRPA1 is requi ...... modulated by algesic stimuli.
@nl
P2093
P2860
P50
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P1476
The ion channel TRPA1 is requi ...... s modulated by algesic stimuli
@en
P2093
Birgit Adam
Christopher M Martin
L Ashley Blackshaw
Nicole J Cooper
Tracey A O'Donnell
P2860
P304
2084-2095.e3
P356
10.1053/J.GASTRO.2009.07.048
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P50
P577
2009-07-24T00:00:00Z