Thrombospondin-1/CD47 blockade following ischemia-reperfusion injury is tissue protective.
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Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47Activated CD47 regulates multiple vascular and stress responses: implications for acute kidney injury and its managementThrombospondins as key regulators of synaptogenesis in the central nervous systemCD47 update: a multifaceted actor in the tumour microenvironment of potential therapeutic interestCardiac CD47 drives left ventricular heart failure through Ca2+-CaMKII-regulated induction of HDAC3.Thrombospondin-1 activation of signal-regulatory protein-α stimulates reactive oxygen species production and promotes renal ischemia reperfusion injury.Dendritic cell-derived thrombospondin-1 is critical for the generation of the ocular surface Th17 response to desiccating stress.Age-dependent regulation of skeletal muscle mitochondria by the thrombospondin-1 receptor CD47.CD47 deficiency protects mice from diet-induced obesity and improves whole body glucose tolerance and insulin sensitivity.CD47 blockade reduces ischemia-reperfusion injury and improves outcomes in a rat kidney transplant model.Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1.The matricellular protein thrombospondin-1 globally regulates cardiovascular function and responses to stress via CD47.Diminished adhesion and activation of platelets and neutrophils with CD47 functionalized blood contacting surfaces.Therapeutic Targeting of CD47 to Modulate Tissue Responses to Ischemia and Radiation.Activation of parenchymal CD47 promotes renal ischemia-reperfusion injury.Identification of TAX2 peptide as a new unpredicted anti-cancer agent.CD47 deficiency confers cell and tissue radioprotection by activation of autophagy.Advances and challenges in skeletal muscle angiogenesis.CD47 signaling pathways controlling cellular differentiation and responses to stress.Intravenous delivery of siRNA targeting CD47 effectively inhibits melanoma tumor growth and lung metastasis.Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow.Thrombospondin-1 and CD47 regulation of cardiac, pulmonary and vascular responses in health and disease.Thrombospondin-1, free radicals, and the coronary microcirculation: the aging conundrum.Regulation of cellular redox signaling by matricellular proteins in vascular biology, immunology, and cancerDivergent modulation of normal and neoplastic stem cells by thrombospondin-1 and CD47 signaling.CD47 blockade reduces ischemia/reperfusion injury in donation after cardiac death rat kidney transplantation.CD63, MHC class 1, and CD47 identify subsets of extracellular vesicles containing distinct populations of noncoding RNAs.TSP1-CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction.CD47
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P2860
Thrombospondin-1/CD47 blockade following ischemia-reperfusion injury is tissue protective.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on December 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Thrombospondin-1/CD47 blockade ...... n injury is tissue protective.
@en
Thrombospondin-1/CD47 blockade ...... n injury is tissue protective.
@nl
type
label
Thrombospondin-1/CD47 blockade ...... n injury is tissue protective.
@en
Thrombospondin-1/CD47 blockade ...... n injury is tissue protective.
@nl
prefLabel
Thrombospondin-1/CD47 blockade ...... n injury is tissue protective.
@en
Thrombospondin-1/CD47 blockade ...... n injury is tissue protective.
@nl
P2093
P2860
P1476
Thrombospondin-1/CD47 blockade following ischemia-reperfusion injury is tissue protective
@en
P2093
Hubert B Shih
Jeffrey S Isenberg
Justin B Maxhimer
P2860
P304
P356
10.1097/PRS.0B013E3181BCEEC3
P407
P577
2009-12-01T00:00:00Z