Role of two strictly conserved residues in nucleotide flipping and N-glycosylic bond cleavage by human thymine DNA glycosylase.
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Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNAThymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sitesDNA glycosylases: in DNA repair and beyondAn unprecedented nucleic acid capture mechanism for excision of DNA damageExcision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylationAnalysis of substrate specificity of Schizosaccharomyces pombe Mag1 alkylpurine DNA glycosylaseNon-productive DNA damage binding by DNA glycosylase-like protein Mag2 from Schizosaccharomyces pombeActivity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pHCrystal Structure of Human Methyl-Binding Domain IV Glycosylase Bound to Abasic DNAStructural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residuesRole of base excision repair in maintaining the genetic and epigenetic integrity of CpG sitesMBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological rolesDependence of substrate binding and catalysis on pH, ionic strength, and temperature for thymine DNA glycosylase: Insights into recognition and processing of G·T mispairsThymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNAE2-mediated small ubiquitin-like modifier (SUMO) modification of thymine DNA glycosylase is efficient but not selective for the enzyme-product complex.Recent advances in the structural mechanisms of DNA glycosylasesThe effect of a G:T mispair on the dynamics of DNAStoichiometry and affinity for thymine DNA glycosylase binding to specific and nonspecific DNADifferential stabilities and sequence-dependent base pair opening dynamics of Watson-Crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine.Lesion search and recognition by thymine DNA glycosylase revealed by single molecule imaging.A density functional theory study on the kinetics and thermodynamics of N-glycosidic bond cleavage in 5-substituted 2'-deoxycytidinesEarly steps of active DNA demethylation initiated by ROS1 glycosylase require three putative helix-invading residues.Divergent mechanisms for enzymatic excision of 5-formylcytosine and 5-carboxylcytosine from DNA.Structural Basis for Excision of 5-Formylcytosine by Thymine DNA Glycosylase.Role of Base Excision "Repair" Enzymes in Erasing Epigenetic Marks from DNABase excision repair of oxidative DNA damage: from mechanism to disease.Replication-Dependent Unhooking of DNA Interstrand Cross-Links by the NEIL3 Glycosylase.A discontinuous DNA glycosylase domain in a family of enzymes that excise 5-methylcytosine.Base-flipping dynamics from an intrahelical to an extrahelical state exerted by thymine DNA glycosylase during DNA repair process.Defining the impact of sumoylation on substrate binding and catalysis by thymine DNA glycosylase.
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P2860
Role of two strictly conserved residues in nucleotide flipping and N-glycosylic bond cleavage by human thymine DNA glycosylase.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 30 October 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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name
Role of two strictly conserved ...... human thymine DNA glycosylase.
@en
Role of two strictly conserved ...... human thymine DNA glycosylase.
@nl
type
label
Role of two strictly conserved ...... human thymine DNA glycosylase.
@en
Role of two strictly conserved ...... human thymine DNA glycosylase.
@nl
prefLabel
Role of two strictly conserved ...... human thymine DNA glycosylase.
@en
Role of two strictly conserved ...... human thymine DNA glycosylase.
@nl
P2093
P2860
P356
P1476
Role of two strictly conserved ...... human thymine DNA glycosylase.
@en
P2093
Alexander C Drohat
Atanu Maiti
Michael T Morgan
P2860
P304
36680-36688
P356
10.1074/JBC.M109.062356
P407
P577
2009-10-30T00:00:00Z