Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges - Wikidata - awgldk - TriplyDB

Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges

Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges

http://www.wikidata.org/entity/Q37480232

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Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease Nuclear DNA damage signalling to mitochondria in ageing Mitochondria Initiate and Regulate Sarcopenia Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway An Artificial Reaction Promoter Modulates Mitochondrial Functions via Chemically Promoting Protein Acetylation.Caloric restriction increases brain mitochondrial calcium retention capacity and protects against excitotoxicity SIRT3 in Neural Stem Cells Attenuates Microglia Activation-Induced Oxidative Stress Injury Through Mitochondrial Pathway.The NAD+-Dependent Family of Sirtuins in Cerebral Ischemia and Preconditioning.Cockayne syndrome: Clinical features, model systems and pathways.Impact of intermittent fasting on health and disease processes.Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance.The role of caloric load and mitochondrial homeostasis in the regulation of the NLRP3 inflammasome.Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms.Mitophagy in neurodegeneration and aging.Mitochondrial Sirtuins and Molecular Mechanisms of Aging.Nutrient Sensing and the Oxidative Stress Response.Metabolic Dysfunction in Parkinson's Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism.Emerging Roles of Sirtuins in Ischemic Stroke.DNP, mitochondrial uncoupling, and neuroprotection: A little dab'll do ya.Sirt1-Sirt3 axis regulates human blood-brain barrier permeability in response to ischemia.3-Hydroxybutyrate regulates energy metabolism and induces BDNF expression in cerebral cortical neurons.Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice.Towards an Understanding of Energy Impairment in Huntington's Disease Brain.Decreased Neuron Number and Synaptic Plasticity in SIRT3-Knockout Mice with Poor Remote Memory.SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress.The Interrelation between Reactive Oxygen Species and Autophagy in Neurological Disorders.Intermittent metabolic switching, neuroplasticity and brain health.Exercise and BDNF reduce Aβ production by enhancing α-secretase processing of APP.NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair.NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.Recent insights into the cellular and molecular determinants of aging.The Mitochondrial Acylome Emerges: Proteomics, Regulation by Sirtuins, and Metabolic and Disease Implications.SIRT3: A New Regulator of Cardiovascular Diseases.Astrocytic JWA deletion exacerbates dopaminergic neurodegeneration by decreasing glutamate transporters in mice.Aerobic Interval Training Regulated SIRT3 Attenuates High-Fat-Diet-Associated Cognitive Dysfunction.Sirt3-Mediated Autophagy Contributes to Resveratrol-Induced Protection against ER Stress in HT22 Cells.Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States.Inhibition of prolyl hydroxylases alters cell metabolism and reverses pre-existing diastolic dysfunction in mice Enhancing and Extending Biological Performance and Resilience

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Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges

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J.CMET.2015.10.013

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Cell Metabolism

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Mitochondrial SIRT3 Mediates A ...... olic and Excitatory Challenges

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Aiwu Cheng

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Chinmoyee Maharana

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Daoyuan Lu

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Krisztina Marosi

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Magdalena Misiak

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Mark P Mattson

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Ruiqian Wan

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Vilhelm A Bohr

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Wei Peng

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Ye Zhou

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The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase

Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration

Excitotoxic and excitoprotective mechanisms: abundant targets for the prevention and treatment of neurodegenerative disorders

Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

Energy intake and exercise as determinants of brain health and vulnerability to injury and disease

Hormesis defined

Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation

Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

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128-142

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