Design, synthesis, and evaluation of potent, nonpeptidic mimetics of second mitochondria-derived activator of caspases.

Design, synthesis, and evaluation of potent, nonpeptidic mimetics of second mitochondria-derived activator of caspases.

Item
http://www.wikidata.org/entity/Q37481457
Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity.Potent and selective small-molecule inhibitors of cIAP1/2 proteins reveal that the binding of Smac mimetics to XIAP BIR3 is not required for their effective induction of cell death in tumor cells.A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment.Design of small-molecule peptidic and nonpeptidic Smac mimetics.A potent bivalent Smac mimetic (SM-1200) achieving rapid, complete, and durable tumor regression in mice.Importance of ligand reorganization free energy in protein-ligand binding-affinity prediction.cIAP2 as a therapeutic target in colorectal cancer and other malignancies.Inhibitor of apoptosis protein family as diagnostic markers and therapeutic targets of colorectal cancer.Dimeric Macrocyclic Antagonists of Inhibitor of Apoptosis Proteins for the Treatment of Cancer.Design and synthesis of a simplified inhibitor for XIAP-BIR3 domain.
P2860

Design, synthesis, and evaluation of potent, nonpeptidic mimetics of second mitochondria-derived activator of caspases.

Item
http://www.wikidata.org/entity/Q37481457
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Design, synthesis, and evaluat ...... derived activator of caspases.
@en
Design, synthesis, and evaluat ...... derived activator of caspases.
@nl
type
label
Design, synthesis, and evaluat ...... derived activator of caspases.
@en
Design, synthesis, and evaluat ...... derived activator of caspases.
@nl
prefLabel
Design, synthesis, and evaluat ...... derived activator of caspases.
@en
Design, synthesis, and evaluat ...... derived activator of caspases.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P921
P932
P356
P1433
P1476
Design, synthesis, and evaluat ...... derived activator of caspases.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P921
P932