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Pharmacological characteristics and clinical applications of K201.

Pharmacological characteristics and clinical applications of K201.

http://www.wikidata.org/entity/Q37481632

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Small-molecule modulators of inward rectifier K+ channels: recent advances and future possibilities.Ryanodine receptor channelopathies.JTV519 (K201) reduces sarcoplasmic reticulum Ca²⁺ leak and improves diastolic function in vitro in murine and human non-failing myocardium Ryanodine receptor mutations in arrhythmia: The continuing mystery of channel dysfunction.Novel therapeutic targets in the management of atrial fibrillation.Cardiac ryanodine receptor in metabolic syndrome: is JTV519 (K201) future therapy?Fixing ryanodine receptor Ca leak - a novel therapeutic strategy for contractile failure in heart and skeletal muscle.An optogenetic arrhythmia model to study catecholaminergic polymorphic ventricular tachycardia mutations.Effects of JTV-519 on stretch-induced manifestations of mechanoelectric feedback.Theophylline-Induced Left Ventricular Relaxation Disturbance in Magnesium-Deficient Rats: Improvement by K201, a Novel 1,4-Benzothiazepine Derivative

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Pharmacological characteristics and clinical applications of K201.

http://www.wikidata.org/entity/Q37481632

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on May 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Pharmacological characteristics and clinical applications of K201.

@en

Pharmacological characteristics and clinical applications of K201.

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type

label

Pharmacological characteristics and clinical applications of K201.

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Pharmacological characteristics and clinical applications of K201.

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prefLabel

Pharmacological characteristics and clinical applications of K201.

@en

Pharmacological characteristics and clinical applications of K201.

@nl

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Current Clinical Pharmacology

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Pharmacological characteristics and clinical applications of K201.

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Ken Shimamoto

http://www.w3.org/2001/XMLSchema#string

Noboru Kaneko

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Ryuko Matsuda

http://www.w3.org/2001/XMLSchema#string

Yoshihito Hata

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Creative Commons Attribution 2.5 Unported

P2860

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias

Structural and functional characterization of endonexin II, a calcium- and phospholipid-binding protein

K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association

Crystal structure of annexin V with its ligand K-201 as a calcium channel activity inhibitor

Cardiac excitation-contraction coupling

Progress in the understanding of cardiac early afterdepolarizations and torsades de pointes: time to revise current concepts.

Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2.

Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction.

Defective regulation of interdomain interactions within the ryanodine receptor plays a key role in the pathogenesis of heart failure.

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126-131

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scholarly article

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10.2174/157488409788184972

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19442077

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