Defective regulation of interdomain interactions within the ryanodine receptor plays a key role in the pathogenesis of heart failure.
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Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunctionIn cardiomyocytes, binding of unzipping peptide activates ryanodine receptor 2 and reciprocally inhibits calmodulin bindingK201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulumDefective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing heartsStructural and functional characterization of ryanodine receptor-natrin toxin interactionCatecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor.Defective regulation of the ryanodine receptor induces hypertrophy in cardiomyocytes.Intracellular translocation of calmodulin and Ca2+/calmodulin-dependent protein kinase II during the development of hypertrophy in neonatal cardiomyocytes.Ryanodine receptor channelopathies.FRET-based trilateration of probes bound within functional ryanodine receptors.The ryanodine receptor in cardiac physiology and disease.Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca(2+) release in heart failure.A low-dose β1-blocker in combination with milrinone improves intracellular Ca2+ handling in failing cardiomyocytes by inhibition of milrinone-induced diastolic Ca2+ leakage from the sarcoplasmic reticulumRegulation of Ryanodine Receptor Ion Channels Through Posttranslational Modifications.Calcium and arrhythmogenesis.Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca²⁺release leading to catecholaminergic polymorphic ventricular tachycardia.Aberrant interaction of calmodulin with the ryanodine receptor develops hypertrophy in the neonatal cardiomyocyteOxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity.The effect of K201 on isolated working rabbit heart mechanical function during pharmacologically induced Ca2+ overload.Recombinant Atrial Natriuretic Peptide Prevents Aberrant Ca2+ Leakage through the Ryanodine Receptor by Suppressing Mitochondrial Reactive Oxygen Species Production Induced by Isoproterenol in Failing Cardiomyocytes.New signaling pathways associated with increased cardiac adenylyl cyclase 6 expression: implications for possible congestive heart failure therapy.Modeling a ryanodine receptor N-terminal domain connecting the central vestibule and the corner clamp region.Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts.In vivo and in vitro cardiac responses to beta-adrenergic stimulation in volume-overload heart failureRyanodine receptor-mediated arrhythmias and sudden cardiac death.Alternative splicing of RyR1 alters the efficacy of skeletal EC coupling.Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor.Pharmacological characteristics and clinical applications of K201.Ca handling during excitation-contraction coupling in heart failure.IP(3) receptors: toward understanding their activation.Ryanodine receptors: structure and function.Structural and functional interactions within ryanodine receptor.ARVC-related mutations in divergent region 3 alter functional properties of the cardiac ryanodine receptor.FK506-binding proteins 12 and 12.6 (FKBPs) as regulators of cardiac Ryanodine Receptors: Insights from new functional and structural knowledge.Ryanodine receptors are targeted by anti-apoptotic Bcl-XL involving its BH4 domain and Lys87 from its BH3 domainToward decrypting the allosteric mechanism of the ryanodine receptor based on coarse-grained structural and dynamic modeling.The emerging role of calmodulin regulation of RyR2 in controlling heart rhythm, the progression of heart failure and the antiarrhythmic action of dantrolene.Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon beta-adrenergic stimulation in normal and failing hearts.CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift.Effects of peptide C corresponding to the Glu724-Pro760 region of the II-III loop of the DHP (dihydropyridine) receptor alpha1 subunit on the domain- switch-mediated activation of RyR1 (ryanodine receptor 1) Ca2+ channels.
P2860
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P2860
Defective regulation of interdomain interactions within the ryanodine receptor plays a key role in the pathogenesis of heart failure.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Defective regulation of interd ...... pathogenesis of heart failure.
@ast
Defective regulation of interd ...... pathogenesis of heart failure.
@en
Defective regulation of interd ...... pathogenesis of heart failure.
@nl
type
label
Defective regulation of interd ...... pathogenesis of heart failure.
@ast
Defective regulation of interd ...... pathogenesis of heart failure.
@en
Defective regulation of interd ...... pathogenesis of heart failure.
@nl
prefLabel
Defective regulation of interd ...... pathogenesis of heart failure.
@ast
Defective regulation of interd ...... pathogenesis of heart failure.
@en
Defective regulation of interd ...... pathogenesis of heart failure.
@nl
P2093
P1433
P1476
Defective regulation of interd ...... pathogenesis of heart failure.
@en
P2093
Masafumi Yano
Masahiro Doi
Masunori Matsuzaki
Noriaki Ikemoto
Shigeki Kobayashi
Shinichi Okuda
Takahiro Tokuhisa
Takeshi Yamamoto
Tetsuro Oda
Tomoko Ohkusa
P304
P356
10.1161/CIRCULATIONAHA.104.507921
P407
P577
2005-06-20T00:00:00Z