Human cancers converge at the HIF-2alpha oncogenic axis. - Wikidata - awgldk - TriplyDB

Human cancers converge at the HIF-2alpha oncogenic axis.

Human cancers converge at the HIF-2alpha oncogenic axis.

http://www.wikidata.org/entity/Q37482150

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Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy Hypoxia-inducible factors and the response to hypoxic stress Hypoxia signaling pathways: modulators of oxygen-related organelles Renal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cysts Allosteric inhibition of hypoxia inducible factor-2 with small molecules A robust tool for discriminative analysis and feature selection in paired samples impacts the identification of the genes essential for reprogramming lung tissue to adenocarcinoma Pronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104 Potential role of preoperative conventional MRI including diffusion measurements in assessing epidermal growth factor receptor gene amplification status in patients with glioblastoma Hypoxia-inducible factors have distinct and stage-specific roles during reprogramming of human cells to pluripotency.DNMT3a epigenetic program regulates the HIF-2α oxygen-sensing pathway and the cellular response to hypoxia.Low-frequency ultrasound-induced VEGF suppression and synergy with dendritic cell-mediated anti-tumor immunity in murine prostate cancer cells in vitro.HIF-2alpha-mediated activation of the epidermal growth factor receptor potentiates head and neck cancer cell migration in response to hypoxia.Non-canonical HIF-2α function drives autonomous breast cancer cell growth via an AREG-EGFR/ErbB4 autocrine loop.HIF-2alpha deletion promotes Kras-driven lung tumor development.Loss of the SxxSS motif in a human T-cell factor-4 isoform confers hypoxia resistance to liver cancer: an oncogenic switch in Wnt signaling.Hypoxia-inducible factors modulate the stemness and malignancy of colon cancer cells by playing opposite roles in canonical Wnt signaling.Succinate dehydrogenase-deficient gastrointestinal stromal tumors.Identification of the angiogenic gene signature induced by EGF and hypoxia in colorectal cancer.New insights into the biology of renal cell carcinoma Enhanced tumorigenicity by mitochondrial DNA mild mutations Effect of siRNA-mediated downregulation of VEGF in Tca8113 cells on the activity of monocyte-derived dendritic cells.The Role of Hypoxia and Cancer Stem Cells in Renal Cell Carcinoma Pathogenesis.The twisted survivin connection to angiogenesis The role of hypoxia-inducible factor-2 in digestive system cancers.5-Benzylglycinyl-amiloride kills proliferating and nonproliferating malignant glioma cells through caspase-independent necroptosis mediated by apoptosis-inducing factor The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption The VHL/HIF axis in clear cell renal carcinoma.The oncogene HER2/neu (ERBB2) requires the hypoxia-inducible factor HIF-1 for mammary tumor growth and anoikis resistance PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression HIF2α contributes to antiestrogen resistance via positive bilateral crosstalk with EGFR in breast cancer cells.Role of Mitochondrial DNA Copy Number Alteration in Human Renal Cell Carcinoma.Thrombospondin-2 overexpression in the skin of transgenic mice reduces the susceptibility to chemically induced multistep skin carcinogenesis Hsp90 as a gatekeeper of tumor angiogenesis: clinical promise and potential pitfalls.HIF and the lung: role of hypoxia-inducible factors in pulmonary development and disease.Hypoxia-inducible factors--regulation, role and comparative aspects in tumourigenesis.Targeting NF-κB and HIF-1 pathways for the treatment of cancer: part II.Passing the baton: the HIF switch.Hypoxia inducible factor pathway inhibitors as anticancer therapeutics.HIF expression and the role of hypoxic microenvironments within primary tumours as protective sites driving cancer stem cell renewal and metastatic progression.The hypoxic tumor microenvironment: driving the tumorigenesis of non-small-cell lung cancer.

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P2860

Human cancers converge at the HIF-2alpha oncogenic axis.

http://www.wikidata.org/entity/Q37482150

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 02 December 2009

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Human cancers converge at the HIF-2alpha oncogenic axis.

@en

Human cancers converge at the HIF-2alpha oncogenic axis.

@nl

type

label

Human cancers converge at the HIF-2alpha oncogenic axis.

@en

Human cancers converge at the HIF-2alpha oncogenic axis.

@nl

prefLabel

Human cancers converge at the HIF-2alpha oncogenic axis.

@en

Human cancers converge at the HIF-2alpha oncogenic axis.

@nl

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PNAS.0906432106

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Proceedings of the National Academy of Sciences of the United States of America

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Human cancers converge at the HIF-2alpha oncogenic axis

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Aleksandra Franovic

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Josianne Payette

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Stephen Lee

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P2860

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

The Hallmarks of Cancer

HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

Targeting HIF-1 for cancer therapy

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

Cancer genes and the pathways they control

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21306-21311

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scholarly article

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10.1073/PNAS.0906432106

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50

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106

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Chet E Holterman

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2009-12-02T00:00:00Z

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40442555

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2795516

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