Phorbol esters induce multidrug resistance in human breast cancer cells.
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Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channelsNonmutagenic mechanisms in carcinogenesis: role of protein kinase C in signal transduction and growth controlProtein kinase Cα mediates erlotinib resistance in lung cancer cells.Involvement of protein kinase C-delta in DNA damage-induced apoptosis.Selective modulation of vinblastine sensitivity by 1,9-dideoxyforskolin and related diterpenes in multidrug resistant tumour cells.Effect of polyunsaturated fatty acids on the drug sensitivity of human tumour cell lines resistant to either cisplatin or doxorubicin.Cross-resistance to tumour promoters in human cancer cell lines resistant to adriamycin or cisplatinRegulation of P-glycoprotein 1 and 2 gene expression and protein activity in two MCF-7/Dox cell line subclones.Phorbol 12-myristate 13-acetate inhibits P-glycoprotein-mediated efflux of digoxin in MDCKII-MDR1 and Caco-2 cell monolayer models.Characterization of a clonal human colon adenocarcinoma line intrinsically resistant to doxorubicinCo-ordinate loss of protein kinase C and multidrug resistance gene expression in revertant MCF-7/Adr breast carcinoma cells.Multidrug resistance: a novel class of membrane-associated transport proteins is identified.Depletion of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) enhances platinum drug sensitivity in human ovarian carcinoma cells.A possible role for a mammalian facilitative hexose transporter in the development of resistance to drugsMolecular mechanisms and clinical implications of reversible protein S-glutathionylation.Molecular analysis of the multidrug transporter, P-glycoprotein.Characteristics of erythroleukemia cells selected for vincristine resistance that have accelerated inducer-mediated differentiation.Signal transduction pathways and transcriptional mechanisms of ABCB1/Pgp-mediated multiple drug resistance in human cancer cells.Protein kinase C-mediated phosphorylation does not regulate drug transport by the human multidrug resistance P-glycoprotein.Phosphorylation of the periplasmic binding protein in two transport systems for arginine incorporation in Escherichia coli K-12 is unrelated to the function of the transport system.Potential role of cyclooxygenase-2 on the regulation of the drug efflux transporter ABCG2 in breast cancer cell lines.Inhibition of protein kinase C-alpha isoform enhances the P-glycoprotein expression and the survival of LoVo human colon adenocarcinoma cells to doxorubicin exposureProtein kinases and multidrug resistance.Suppression of P-glycoprotein gene expression in Hs578T/Dox by the overexpression of caveolin-1.Anticancer drug-mediated induction of multidrug resistance-associated genes and protein kinase C isozymes in the T-lymphoblastoid cell line CCRF-CEM and in blasts from patients with acute lymphoblastic leukemias.A shift from normal to high glucose levels stimulates cell proliferation in drug sensitive MCF-7 human breast cancer cells but not in multidrug resistant MCF-7/ADR cells which overproduce PKC-betaII.Partial inhibition of multidrug resistance by safingol is independent of modulation of P-glycoprotein substrate activities and correlated with inhibition of protein kinase C.Partial restoration of the actin cytoskeleton in transformed Syrian hamster fibroblasts selected for low levels of 'typical' multidrug resistance.Modulation of expression of multidrug resistance gene (mdr-1) by adriamycin.Phosphorylation by protein kinase C and cyclic AMP-dependent protein kinase of synthetic peptides derived from the linker region of human P-glycoprotein.The polyoxyethylene castor oil Cremophor EL modifies multidrug resistance.Differential modulation of doxorubicin toxicity to multidrug and intrinsically drug resistant cell lines by anti-oestrogens and their major metabolites.Protein kinase C: an attractive target for cancer therapy.Regulation of mdr2 P-glycoprotein expression by bile saltsGenistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells.Phorbol ester selectively stimulates the phospholipase D-mediated hydrolysis of phosphatidylethanolamine in multidrug-resistant MCF-7 human breast carcinoma cellsSp1 involvement in the 4beta-phorbol 12-myristate 13-acetate (TPA)-mediated increase in resistance to methotrexate in Chinese hamster ovary cells.Regulation of MDR1 promoter activity in human breast carcinoma cells by protein kinase C isozymes alpha and theta.Role of protein kinase beta isozyme in multidrug resistance in murine leukemia P388/ADR cells.Sequential assessment of multidrug resistance phenotype and measurement of S-phase fraction as predictive markers of breast cancer response to neoadjuvant chemotherapy.
P2860
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P2860
Phorbol esters induce multidrug resistance in human breast cancer cells.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 1988
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Phorbol esters induce multidrug resistance in human breast cancer cells.
@en
Phorbol esters induce multidrug resistance in human breast cancer cells.
@nl
type
label
Phorbol esters induce multidrug resistance in human breast cancer cells.
@en
Phorbol esters induce multidrug resistance in human breast cancer cells.
@nl
prefLabel
Phorbol esters induce multidrug resistance in human breast cancer cells.
@en
Phorbol esters induce multidrug resistance in human breast cancer cells.
@nl
P2093
P2860
P356
P1476
Phorbol esters induce multidrug resistance in human breast cancer cells.
@en
P2093
P2860
P304
P356
10.1073/PNAS.85.2.582
P407
P577
1988-01-01T00:00:00Z